ArticleEuropean journal of immunology1999
Clonal evolution of B cells in transformation from low- to high-grade lymphoma.
Article in European journal of immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 90 citations in OpenAlex.
- Mutational patterns along different evolution paths of follicular lymphoma.Frontiers in oncology · 2022Article
- Composite diffuse large B-cell lymphoma and follicular B-cell lymphoma - case report and review of literature.Maedica · 2014Article
- Diffuse large B-cell lymphoma arising in a composite lymphoma with biclonality by flow cytometry and one monoclonal band by PCR.International journal of clinical and experimental pathology · 2014Article
- Immunoglobulin gene repertoire diversification and selection in the stomach - from gastritis to gastric lymphomas.Frontiers in immunology · 2014Article
- Transformation in follicular lymphoma: biology, prognosis, and therapeutic options.Current oncology reports · 2012Review
- Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma.International journal of hematology · 2010Article
- Richter's transformation in chronic lymphocytic leukemia.Current hematologic malignancy reports · 2007Review
- Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma.Leukemia · 2007Article
- Recent advances in the diagnosis and therapy of Richter's syndrome.Medical oncology (Northwood, London, England) · 2007Review
- Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis.Journal of clinical immunology · 2007Article
- Molecular pathways in follicular lymphoma.Leukemia · 2007Review
- Clinical and molecular prognostic factors in follicular lymphoma.Current oncology reports · 2006Review
- Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis.Virchows Archiv : an international journal of pathology · 2005Review
- Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection.Immunology · 2005Article
- Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl.The Journal of experimental medicine · 2004Article
- Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL).Journal of clinical immunology · 2004Article
- Relationship between the mutational status of VH genes and pathogenesis of diffuse large B-cell lymphoma in Richter's syndrome.Leukemia · 2004Article
- Molecular pathology of primary intraocular lymphoma.Transactions of the American Ophthalmological Society · 2003Article
- Primary malignant lymphoma of the brain: mutation pattern of rearranged immunoglobulin heavy chain gene.Japanese journal of cancer research : Gann · 2002Article
- Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.The Journal of experimental medicine · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
An outcome of low-grade B cell non-Hodgkins's lymphomas is the transformation to high-grade diffuse large B cell lymphomas (DLBL). To investigate the mechanisms of clonal evolution in the transformation to DLBL, we performed longitudinal molecular analyses of immunoglobulin (Ig), V(H)DJ(H) gene sequences expressed in cases of chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and follicular lymphoma (FL) that transformed to DLBL. Among the neoplastic CLL and SLL cells and their respective high-grade transformants, there was no evidence for a clonotypic shift or acquired mutations in the expressed Ig V(H)DJ(H) gene segments, as further confirmed by a specific and sensitive PCR-single strand polymorphism analysis. In contrast, among the FL cells there was a high degree of intraclonal diversification with highly divergent V(H)DJ(H) gene sequences. Despite this intraclonal heterogeneity, the related DLBL expressed a collinear but unique V(H)DJ(H) gene sequence. The intraclonal genealogical tree for the FL case demonstrated that the DLBL emerged in association with unique V(H)DJ(H) gene mutational events. Among the intraclonal FL and related DLBL transformants, the nature and distribution of the Ig V(H)DJ(H) gene mutations were consistent with antigenic selection. Thus, clonal evolution in the transformation from low- to high-grade B cell lymphoma may involve distinct pathways which vary according to the cellular origin and the type of the progenitor B cell tumor.
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10229093PMC4625534W2079162000What OpenQuestion holds
Registered trials
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