ArticleThe EMBO journal1999
Phenotypic switching in Candida albicans is controlled by a SIR2 gene.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Review
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- An epigenetic change in a moth is generated by temperature and transmitted to many subsequent generations mediated by RNA.PloS one · 2024Article
- Sirtuins are Not Conserved Longevity Genes.Life metabolism · 2022Article
- Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2022Review
- Contributions of a Histone Deacetylase (SirT2/Hst2) toJournal of fungi (Basel, Switzerland) · 2022Article
- Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases.Frontiers in physiology · 2022Review
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- The Roles of Chromatin Accessibility in Regulating theJournal of fungi (Basel, Switzerland) · 2021Review
- Chromatin Structure and Drug Resistance inJournal of fungi (Basel, Switzerland) · 2020Review
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- Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control.Frontiers in microbiology · 2020Review
- Chromatin architecture and virulence-related gene expression in eukaryotic microbial pathogens.Current genetics · 2019Review
- A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi.Microbiology spectrum · 2017Review
- Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans.Scientific reports · 2017Article
- Candida albicans repetitive elements display epigenetic diversity and plasticity.Scientific reports · 2016Article
- Histone Deacetylases and Their Inhibition in Candida Species.Frontiers in microbiology · 2016Review
- Histone deacetylase-mediated morphological transition in Candida albicans.Journal of microbiology (Seoul, Korea) · 2015Review
- Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We report the cloning of a gene from the human fungal pathogen Candida albicans with sequence and functional similarity to the Saccharomyces cerevisiae SIR2 gene. Deletion of the gene in C. albicans produces a dramatic phenotype: variant colony morphologies arise at frequencies as high as 1 in 10. The morphologies resemble those described previously as part of a phenotypic switching system proposed to contribute to pathogenesis. Deletion of SIR2 also produces a high frequency of karyotypic changes. These and other results are consistent with a model whereby Sir2 controls phenotypic switching and chromosome stability in C.albicans by organizing chromatin structure.
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