ArticleThe EMBO journal1999
E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 93 citations in OpenAlex.
- Cell-type-agnostic differential gene expression uncovers conserved principles of cellular regulation.bioRxiv : the preprint server for biology · 2025Article
- Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network Analysis.Cancer management and research · 2019Article
- Rapid DNA Synthesis During EarlyGenetics · 2017Article
- Article
- Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells.The Journal of biological chemistry · 2015Article
- HBx protein of hepatitis B virus promotes reinitiation of DNA replication by regulating expression and intracellular stability of replication licensing factor CDC6.The Journal of biological chemistry · 2012Article
- Review
- Mechanisms and pathways of growth failure in primordial dwarfism.Genes & development · 2011Review
- The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing.The EMBO journal · 2010Article
- Study of DNA replication in Drosophila using cell free in vitro system.Cell cycle (Georgetown, Tex.) · 2010Article
- Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum.Eukaryotic cell · 2009Article
- Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.Molecular and cellular biology · 2009Article
- Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development.Developmental biology · 2008Article
- The origin recognition complex is dispensable for endoreplication in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing.The EMBO journal · 2008Article
- Conservation of epigenetic regulation, ORC binding and developmental timing of DNA replication origins in the genus Drosophila.Genetics · 2007Article
- Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.Cancer research · 2007Article
- Article
- Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin.Molecular and cellular biology · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Throughout the cell cycle of Saccharomyces cerevisiae, the level of origin recognition complex (ORC) is constant and ORCs are bound constitutively to replication origins. Replication is regulated by the recruitment of additional factors such as CDC6. ORC components are widely conserved, and it generally has been assumed that they are also stable factors bound to origins throughout the cell cycle. In this report, we show that the level of the ORC1 subunit changes dramatically throughout Drosophila development. The accumulation of ORC1 is regulated by E2F-dependent transcription. In embryos, ORC1 accumulates preferentially in proliferating cells. In the eye imaginal disc, ORC1 accumulation is cell cycle regulated, with high levels in late G1 and S phase. In the ovary, the sub-nuclear distribution of ORC1 shifts during a developmentally regulated switch from endoreplication of the entire genome to amplification of the chorion gene clusters. Furthermore, we find that overexpression of ORC1 alters the pattern of DNA synthesis in the eye disc and the ovary. Thus, replication origin activity appears to be governed in part by the level of ORC1 in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.