ArticlePharmaceutical research1999
Distribution characteristics of levofloxacin and grepafloxacin in rat kidney.
Article in Pharmaceutical research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves.Journal of veterinary science · 2007Trial
- AB-DB: Force-Field parameters, MD trajectories, QM-based data, and Descriptors of Antimicrobials.Scientific data · 2022Article
- Effects of Lysozyme on the Activity of Ionic of Fluoroquinolone Species.Molecules (Basel, Switzerland) · 2018Article
- Renal Drug Transporters and Drug Interactions.Clinical pharmacokinetics · 2017Review
- Prediction of the pharmacokinetics and tissue distribution of levofloxacin in humans based on an extrapolated PBPK model.European journal of drug metabolism and pharmacokinetics · 2016Article
- Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.Antimicrobial agents and chemotherapy · 2014Article
- Disposition kinetics, urinary excretion and dosage regimen of levofloxacin formulation following single intravenous administration in crossbred calves.Veterinary research communications · 2007Article
- Shiga-like toxin II derived from Escherichia coli O157:H7 modifies renal handling of levofloxacin in rats.Antimicrobial agents and chemotherapy · 2002Article
- Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells.British journal of pharmacology · 2002Article
- Transport of levofloxacin in the OK kidney epithelial cell line: interaction with p-aminohippurate transport.Pharmaceutical research · 2001Article
- Transepithelial transport of levofloxacin in the isolated perfused rat kidney.Pharmaceutical research · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo elucidate the renal distribution of quinolones, we examined the uptake of levofloxacin and grepafloxacin in vivo and in rat renal cortical slices.
methodsThe plasma and various tissue concentrations of levofloxacin and grepafloxacin were measured after a bolus injection in rats, and tissue uptake clearance was calculated. Transport characteristics of quinolones in rat renal cortical slices were evaluated.
resultsThe tissue distribution of levofloxacin and grepafloxacin in the kidney was greater than in any other tissue, and the tissue uptake clearances of levofloxacin and grepafloxacin in the kidney cortex were 1.2 and 4.6 ml/min/g tissue, respectively. The uptake of levofloxacin and grepafloxacin in rat renal cortical slices was concentrative, as indicated by slice/medium ratios of 2.3 and 9.6 at 60 min, respectively. The uptake of levofloxacin and grepafloxacin in rat renal cortical slices showed saturation, and was significantly inhibited in the presence of quinidine (p<.05), but not of tetraethylammonium or p-aminohippurate.
conclusionsRenal distribution of levofloxacin and grepafloxacin may be mediated by a specific transport system for quinolones, distinct from the organic cation and organic anion transport systems in the kidney.
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