ReviewPharmaceutical research1999
Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides.
Review in Pharmaceutical research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Cell dehydration enables massive production of engineered membrane vesicles with therapeutic functions.Journal of extracellular vesicles · 2024Article
- Preclinical Safety Assessment of Therapeutic Oligonucleotides.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Nucleic acid-based therapy for coronavirus disease 2019.Heliyon · 2020Review
- Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems.Polymers · 2019Review
- Selective Small Molecule Recognition of RNA Base Pairs.ACS combinatorial science · 2018Article
- Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation.Scientific reports · 2017Article
- Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Article
- A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo.Cancer biology & therapy · 2016Article
- Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.Nucleic acid therapeutics · 2014Review
- Mannosylated chitosan nanoparticles for delivery of antisense oligonucleotides for macrophage targeting.BioMed research international · 2014Article
- Reliable assessment and quantification of the fluorescence-labeled antisense oligonucleotides in vivo.BioMed research international · 2014Article
- Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides.Bioconjugate chemistry · 2012Review
- Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1alpha-oligonucleotide.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
- Bioconjugate-based molecular umbrellas.Bioconjugate chemistry · 2009Review
- Viewing membrane-bound molecular umbrellas by parallax analyses.Journal of the American Chemical Society · 2008Article
- Magnetic nanoparticles in MR imaging and drug delivery.Advanced drug delivery reviews · 2008Review
- Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides.Nucleic acids research · 2008Review
- Dendritic alpha,epsilon-poly(L-lysine)s as delivery agents for antisense oligonucleotides.Pharmaceutical research · 2007Article
- Encapsulation of nucleic acids and opportunities for cancer treatment.Pharmaceutical research · 2007Review
- Gene modulation for treating liver fibrosis.Critical reviews in therapeutic drug carrier systems · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The pharmacodynamic relationships between biodistribution and the ultimate biological effects of antisense agents are considered. The problems and advantages inherent in the use of delivery systems are discussed in the light of further enhancing in vivo pharmacological actions of oligonucleotides.
Indexed as
Identifiers
10227702What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.