ReviewPharmaceutical research1999
Three-dimensional cultures of prostatic cells: tissue models for the development of novel anti-cancer therapies.
Review in Pharmaceutical research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements.Sensors (Basel, Switzerland) · 2020Article
- Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors.BioMed research international · 2020Review
- Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum.Scientific reports · 2017Article
- Rotary bioreactor culture can discern specific behavior phenotypes in Trk-null and Trk-expressing neuroblastoma cell lines.In vitro cellular & developmental biology. Animal · 2014Article
- Cancer research by means of tissue engineering--is there a rationale?Journal of cellular and molecular medicine · 2013Review
- Microgravity assay of neuroblastoma: in vitro aggregation kinetics and organoid morphology correlate with MYCN expression.In vitro cellular & developmental biology. Animal · 2011Article
- Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.Nature reviews. Microbiology · 2010Review
- Characterization of aggregation and protein expression of bovine corneal endothelial cells as microcarrier cultures in a rotating-wall vessel.Cytotechnology · 2000Article
- The effects of three-dimensional cell culture on single myoblasts.In vitro cellular & developmental biology. AnimalArticle
- A novel in vitro three-dimensional skeletal muscle model.In vitro cellular & developmental biology. AnimalArticle
- Restructuring dynamics of DU 145 and LNCaP prostate cancer spheroids.In vitro cellular & developmental biology. AnimalArticle
- Immunohistochemical analysis of differentiation in static and mixed prostate cancer spheroids.Journal of cellular and molecular medicineArticle
- Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction.Journal of cellular and molecular medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review addresses the application of three-dimensional cultures of prostatic cells to the development of novel anti-cancer therapies. A variety of therapeutic agents to combat prostate cancer are currently under development. These include cytotoxins, differentiation agents and, more recently, genetically modified tumor vaccines. Three-dimensional cultures of prostatic cells are increasingly used in preclinical research in the design of new therapies and in the development of delivery strategies for these treatments. These tissue-like structures more realistically model the structural architecture and differentiated function of the human prostate than a cellular monolayer. In doing so, three-dimensional cultures produce an in vivo-like response to therapeutic agents. Advances in tissue engineering have improved the variety, fidelity and quantity of these prostate models. To date, they have been applied to estimate the dose of new drug therapies, evaluate drug penetration into solid tumors, assess the effectiveness of drug combinations, and develop tumor vaccines.
Indexed as
Identifiers
10227701What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.