ArticleJournal of clinical immunology1999
Immunological response in chronic fatigue syndrome following a graded exercise test to exhaustion.
Article in Journal of clinical immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Acute Exercise on Fatigue in People with ME/CFS/SEID: A Meta-analysis.Medicine and science in sports and exercise · 2016Pooled it
- Behavioral and molecular characterization of fatigue-like manifestations triggered by acute restraint stress and LPS or saline.Scientific reports · 2026Article
- A mouse model to study persistent fatigue.Research square · 2026Article
- Postexertional Symptom Exacerbation after Submaximal Exercise in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of COVID-19.Medicine and science in sports and exercise · 2026Article
- Two Different Hemodynamic Responses in ME/CFS Patients with Postural Orthostatic Tachycardia Syndrome During Head-Up Tilt Testing.Journal of clinical medicine · 2024Article
- Article
- Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.Scientific reports · 2020Article
- Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms.World journal of methodology · 2015Review
- Distinct plasma immune signatures in ME/CFS are present early in the course of illness.Science advances · 2015Article
- Avoidance behavior towards physical activity in chronic fatigue syndrome and fibromyalgia: the fear for post-exertional malaise.Clinical rheumatology · 2014Article
- Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome.Clinical and vaccine immunology : CVI · 2013Article
- Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study.Psychological medicine · 2013Article
- Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.Psychophysiology · 2010Article
- Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia.Clinical and vaccine immunology : CVI · 2010Article
- Prospective association between C-reactive protein and fatigue in the coronary artery risk development in young adults study.Biological psychiatry · 2009Article
- Spinal fluid abnormalities in patients with chronic fatigue syndrome.Clinical and diagnostic laboratory immunology · 2005Article
- A status report on chronic fatigue syndrome.Environmental health perspectives · 2002Review
- Evidence for the presence of immune dysfunction in chronic fatigue syndrome.Clinical and diagnostic laboratory immunology · 2002Review
- Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.Clinical and diagnostic laboratory immunology · 2001Article
- Chronic fatigue syndrome: an update.Sports medicine (Auckland, N.Z.) · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
This study was conducted to evaluate the immunological response to an exhaustive treadmill exercise test in 20 female chronic fatigue syndrome patients compared to 14 matched sedentary controls. Venipuncture was performed at baseline and 4 min, 1 hr, and 24 hr postexercise. White blood cells were labeled for monoclonal antibody combinations and were quantified by FACsan. Cytokines were assayed utilizing quantitative RT/PCR. No group difference was seen in VO2peak (28.6 +/- 1.6 vs 30.9 +/- 1.2 ml.kg-1.min-1; P > 0.05). However, 24 hr after exercise the patients' fatigue levels were significantly increased (P < 0.05). The counts of WBC, CD3+ CD8+ cells, CD3+ CD4+ cells, T cells, B cells, natural killer cells, and IFN-gamma changed across time (P's < 0.01). No group differences were seen for any of the immune variables at baseline or after exercise (P's > 0.05). The immune response of chronic fatigue syndrome patients to exhaustive exercise is not significantly different from that of healthy nonphysically active controls.
Indexed as
Identifiers
10226888What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.