ArticleThe Journal of cell biology1999
Separation of propulsive and adhesive traction stresses in locomoting keratocytes.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 165 citations in OpenAlex.
- Statistical and mechanical analysis of multi-pseudopodial locomotion in a testate amoeba, Arcella sp.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Article
- Stress fiber contraction induces cell body rotation in single keratocytes.Biophysics and physicobiology · 2025Article
- Electromagnetic Modulation of Cell Behavior: Unraveling the Positive Impacts in a Comprehensive Review.Annals of biomedical engineering · 2024Review
- Celebrating the creative scientific life of Ken Jacobson.Biophysical journal · 2023Article
- Crawling, waving, inch worming, dilating, and pivoting mechanics of migrating cells: Lessons from Ken Jacobson.Biophysical journal · 2023Review
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- Elastic wrinkling of keratocyte lamellipodia driven by myosin-induced contractile stress.Biophysical journal · 2021Article
- On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.Cell systems · 2020Article
- A minimal mechanosensing model predicts keratocyte evolution on flexible substrates.Journal of the Royal Society, Interface · 2020Article
- Spontaneous migration of cellular aggregates from giant keratocytes to running spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Membrane tension controls adhesion positioning at the leading edge of cells.The Journal of cell biology · 2017Article
- Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions.Scientific reports · 2017Article
- Theoretical analysis of membrane tension in moving cells.Biophysical journal · 2014Article
- Deformation gradients imprint the direction and speed of en masse fibroblast migration for fast healing.The Journal of investigative dermatology · 2013Article
- Cell mediated contraction in 3D cell-matrix constructs leads to spatially regulated osteogenic differentiation.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery.Biology open · 2013Article
- Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration.PloS one · 2013Article
- Cell migration.Comprehensive Physiology · 2012Review
- Mechanobiology of tumor invasion: engineering meets oncology.Critical reviews in oncology/hematology · 2012Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Strong, actomyosin-dependent, pinching tractions in steadily locomoting (gliding) fish keratocytes revealed by traction imaging present a paradox, since only forces perpendicular to the direction of locomotion are apparent, leaving the actual propulsive forces unresolved. When keratocytes become transiently "stuck" by their trailing edge and adopt a fibroblast-like morphology, the tractions opposing locomotion are concentrated into the tail, leaving the active pinching and propulsive tractions clearly visible under the cell body. Stuck keratocytes can develop approximately 1 mdyn (10,000 pN) total propulsive thrust, originating in the wings of the cell. The leading lamella develops no detectable propulsive traction, even when the cell pulls on its transient tail anchorage. The separation of propulsive and adhesive tractions in the stuck phenotype leads to a mechanically consistent hypothesis that resolves the traction paradox for gliding keratocytes: the propulsive tractions driving locomotion are normally canceled by adhesive tractions resisting locomotion, leaving only the pinching tractions as a resultant. The resolution of the traction pattern into its components specifies conditions to be met for models of cytoskeletal force production, such as the dynamic network contraction model (Svitkina, T.M., A.B. Verkhovsky, K.M. McQuade, and G.G. Borisy. 1997. J. Cell Biol. 139:397-415). The traction pattern associated with cells undergoing sharp turns differs markedly from the normal pinching traction pattern, and can be accounted for by postulating an asymmetry in contractile activity of the opposed lateral wings of the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.