ArticleInfection and immunity1999
Humoral immune responses to Neisseria meningitidis in children.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Comparison and correlation of neisseria meningitidis serogroup B immunologic assay results and human antibody responses following three doses of the Norwegian meningococcal outer membrane vesicle vaccine MenBvac.Infection and immunity · 2006Trial
- Understanding the immune responses to the meningococcal strain-specific vaccine MeNZB measured in studies of infants.Clinical and vaccine immunology : CVI · 2006Trial
- In Vitro Pre-Clinical Evaluation of a Gonococcal Trivalent Candidate Vaccine Identified by Transcriptomics.Vaccines · 2023Article
- Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis.mBio · 2018Article
- A large portion of meningococcal antigen typing system-negative meningococcal strains from spain is killed by sera from adolescents and infants immunized with 4CMenB.Clinical and vaccine immunology : CVI · 2015Article
- Development of a fluorescent-bead-based multiplex immunoassay to determine immunoglobulin G subclass responses to Neisseria meningitidis serogroup A and C polysaccharides.Clinical and vaccine immunology : CVI · 2008Article
- Social mixing with other children during infancy enhances antibody response to a pneumococcal conjugate vaccine in early childhood.Clinical and vaccine immunology : CVI · 2007Article
- Serum antibody responses in Ethiopian meningitis patients infected with Neisseria meningitidis serogroup A sequence type 7.Clinical and vaccine immunology : CVI · 2007Article
- Improved method to calculate the antibody avidity index.Journal of clinical laboratory analysis · 2007Article
- Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis.Journal of neuroinflammation · 2006Article
- Meningococcal vaccines.Paediatric drugs · 2004Review
- Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans.Infection and immunity · 2002Article
- Article
- Detection of complement-mediated antibody-dependent bactericidal activity in a fluorescence-based serum bactericidal assay for group B Neisseria meningitidis.Journal of clinical microbiology · 2000Article
- Functional activities and immunoglobulin variable regions of human and murine monoclonal antibodies specific for the P1.7 PorA protein loop of Neisseria meningitidis.Infection and immunity · 2000Article
- Cellular immune responses to Neisseria meningitidis in children.Infection and immunity · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
An understanding of the nature of immunity to serogroup B meningococci in childhood is necessary in order to establish the reasons for poor responses to candidate vaccines in infancy. We sought to examine the nature of humoral immune responses following infection in relation to age. Serum bactericidal activity was poor in children under 12 months of age despite recent infection with Neisseria meningitidis. The highest levels of bactericidal activity were seen in children over 10 years of age. However, infants produced levels of total immunoglobulin G (IgG) and IgG subclass antibodies similar to those in older children in a meningococcal enzyme-linked immunosorbent assay. Most antibody was of the IgG1 and IgG3 subclasses. This striking age dependency of bactericidal antibody response following infection is not apparently due to failure of class switching in infants but might be due to qualitative differences in antibody specificity or affinity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.