ArticleInfection and immunity1999
Molecular characterization of a flagellar export locus of Helicobacter pylori.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Unveiling a missing component of the atypical type IV secretion system required for natural transformation of Helicobacter pylori.PLoS pathogens · 2026Article
- Unveiling a missing component of the atypical type IV secretion system required for natural transformation ofbioRxiv : the preprint server for biology · 2026Article
- The impact of the flagellar protein genemSphere · 2025Article
- Loss of a Cardiolipin Synthase inJournal of bacteriology · 2019Article
- Requirement of the flagellar protein export apparatus component FliO for optimal expression of flagellar genes in Helicobacter pylori.Journal of bacteriology · 2014Article
- Themes and Variations: Regulation of RpoN-Dependent Flagellar Genes across Diverse Bacterial Species.Scientifica · 2014Review
- Prevalence of horB gene among the Helicobacter pylori strains isolated from dyspeptic patients: first report from Iran.Internal and emergency medicine · 2012Article
- The zinc-ribbon domain of Helicobacter pylori HP0958: requirement for RpoN accumulation and possible roles of homologs in other bacteria.Microbial informatics and experimentation · 2011Article
- Detailed in vivo analysis of the role of Helicobacter pylori Fur in colonization and disease.Infection and immunity · 2010Article
- Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906.Journal of bacteriology · 2005Article
- Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Helicobacter pylori strain 26695.Journal of bacteriology · 2004Article
- Failure of surface ring mutant strains of Helicobacter mustelae to persistently infect the ferret stomach.Infection and immunity · 2003Article
- Polymorphism of flagellin A gene in Helicobacter pylori.World journal of gastroenterology · 2001Article
- Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr.Infection and immunity · 2001Article
- Mutational analysis of genes encoding the early flagellar components of Helicobacter pylori: evidence for transcriptional regulation of flagellin A biosynthesis.Journal of bacteriology · 2000Article
- Involvement of a plasmid in virulence of Campylobacter jejuni 81-176.Infection and immunity · 2000Article
- Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells.Infection and immunity · 2000Article
- Molecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility.Journal of bacteriology · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motility of Helicobacter species has been shown to be essential for successful colonization of the host. We have investigated the organization of a flagellar export locus in Helicobacter pylori. A 7-kb fragment of the H. pylori CCUG 17874 genome was cloned and sequenced, revealing an operon comprising an open reading frame of unknown function (ORF03), essential housekeeping genes (ileS and murB), flagellar export genes (fliI and fliQ), and a homolog to a gene implicated in virulence factor transport in other pathogens (virB11). A promoter for this operon, showing similarity to the Escherichia coli sigma70 consensus, was identified by primer extension. Cotranscription of the genes in the operon was demonstrated by reverse transcription-PCR, and transcription of virB11, fliI, fliQ, and murB was detected in human or mouse biopsies obtained from infected hosts. The genetic organization of this locus was conserved in a panel of H. pylori clinical isolates. Engineered fliI and fliQ mutant strains were completely aflagellate and nonmotile, whereas a virB11 mutant still produced flagella. The fliI and fliQ mutant strains produced reduced levels of flagellin and the hook protein FlgE. Production of OMP4, a member of the outer membrane protein family identified in H. pylori 26695, was reduced in both the virB11 mutant and the fliI mutant, suggesting related functions of the virulence factor export protein (VirB11) and the flagellar export component (FliI).
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