ArticleAnnals of the rheumatic diseases1999
Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming.PloS one · 2013Trial
- Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment.Nature communications · 2025Article
- Chemokines and chemokine receptors as promising targets in rheumatoid arthritis.Frontiers in immunology · 2023Review
- Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O.Frontiers in immunology · 2021Review
- Role of Chemokines and Chemokine Receptors in Rheumatoid Arthritis.ImmunoTargets and therapy · 2020Review
- Article
- Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis.Rheumatology (Oxford, England) · 2018Article
- A cross-sectional study: serum CCL3/MIP-1α levels may reflect lumbar intervertebral disk degeneration in Han Chinese people.Journal of pain research · 2018Article
- Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.Bioorganic & medicinal chemistry · 2012Article
- Modified huo-luo-xiao-ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymes.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis.Annals of the rheumatic diseases · 2011Article
- Release of the soluble urokinase-type plasminogen activator receptor (suPAR) by activated neutrophils in rheumatoid arthritis.Inflammation · 2010Article
- High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.Arthritis research & therapy · 2010Article
- Neonatal neutrophils with prolonged survival secrete mediators associated with chronic inflammation.Neonatology · 2010Article
- Accelerated development of arthritis in mice lacking endothelial selectins.Arthritis research & therapy · 2005Article
- A novel mechanism for the regulation of IFN-gamma inducible protein-10 expression in rheumatoid arthritis.Arthritis research & therapy · 2003Article
- The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).Arthritis research · 2001Article
- Expression of vascular endothelial growth factor by synovial fluid neutrophils in rheumatoid arthritis (RA).Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the contribution made by synovial fluid (SF) neutrophils to the augmented expression of macrophage inflammatory protein 1 alpha (MIP-1alpha) in rheumatoid arthritis (RA).
methodsNeutrophils were isolated from samples of SF from RA patients and peripheral blood (PB) samples from RA patients and healthy controls. Cell associated MIP-1alpha was visualised immunohistochemically, and cell associated MIP-1alpha as well as MIP-1alpha secreted into the SF was assayed by ELISA. Steady state expression of MIP-1alpha mRNA was assessed by reverse transcription polymerase chain reaction (RT-PCR).
resultsFreshly isolated SF neutrophils contained significantly higher concentrations of both MIP-1alpha protein and its transcript than PB neutrophils from either RA patients or healthy controls; incubation in the absence or presence of tumour necrosis factor alpha for 24 hours resulted in a significant increase in MIP-1alpha secretion by RA SF neutrophils compared with neutrophils obtained from either normal PB or RA PB; and expression of MIP-1alpha by SF neutrophils was well correlated with both RA disease activity and SF mononuclear cell (MNC) counts.
conclusionExpression and secretion of MIP-1alpha by SF neutrophils may be indicative of local and systemic inflammation in RA. Moreover, this C-C chemokine may contribute to the recruitment of MNCs from the bloodstream into synovial joints and tissues.
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