ArticleGenetics1999
RNA polymerase I transcription in a Brassica interspecific hybrid and its progenitors: Tests of transcription factor involvement in nucleolar dominance.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance.The plant genome · 2025Review
- Reaching for the off switch in nucleolar dominance.The Plant journal : for cell and molecular biology · 2023Article
- The fate of 35S rRNA genes in the allotetraploid grass Brachypodium hybridum.The Plant journal : for cell and molecular biology · 2020Article
- Regulation of Nucleolar Dominance inGenetics · 2020Article
- Ribosomal DNA loci derived from Brachypodium stacei are switched off for major parts of the life cycle of Brachypodium hybridum.Journal of experimental botany · 2019Article
- Epigenetic perspectives on the evolution and domestication of polyploid plant and crops.Current opinion in plant biology · 2018Review
- Chromosome-specific NOR inactivation explains selective rRNA gene silencing and dosage control in Arabidopsis.Genes & development · 2016Article
- Nucleolar dominance and ribosomal RNA gene silencing.Current opinion in cell biology · 2010Article
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- Mechanisms of genomic rearrangements and gene expression changes in plant polyploids.BioEssays : news and reviews in molecular, cellular and developmental biology · 2006Review
- Organization, differential expression and methylation of rDNA in artificial Solanum allopolyploids.Plant molecular biology · 2004Article
- Cloning and characterization of leaf cDNAs that are differentially expressed between wheat hybrids and their parents.Molecular genetics and genomics : MGG · 2003Article
- The dominance of alleles controlling self-incompatibility in Brassica pollen is regulated at the RNA level.The Plant cell · 2002Article
- Transcription and tyranny in the nucleolus: the organization, activation, dominance and repression of ribosomal RNA genes.The arabidopsis book · 2002Article
- Restricted chromosomal silencing in nucleolar dominance.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Nucleolar dominance: uniparental gene silencing on a multi-megabase scale in genetic hybrids.Plant molecular biology · 2000Review
- Comparative analysis of DNA methylation in tobacco heterochromatic sequences.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- rRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switch.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In interspecific hybrids or allopolyploids, often one parental set of ribosomal RNA genes is transcribed and the other is silent, an epigenetic phenomenon known as nucleolar dominance. Silencing is enforced by cytosine methylation and histone deacetylation, but the initial discrimination mechanism is unknown. One hypothesis is that a species-specific transcription factor is inactivated, thereby silencing one set of rRNA genes. Another is that dominant rRNA genes have higher binding affinities for limiting transcription factors. A third suggests that selective methylation of underdominant rRNA genes blocks transcription factor binding. We tested these hypotheses using Brassica napus (canola), an allotetraploid derived from B. rapa and B. oleracea in which only B. rapa rRNA genes are transcribed. B. oleracea and B. rapa rRNA genes were active when transfected into protoplasts of the other species, which argues against the species-specific transcription factor model. B. oleracea and B. rapa rRNA genes also competed equally for the pol I transcription machinery in vitro and in vivo. Cytosine methylation had no effect on rRNA gene transcription in vitro, which suggests that transcription factor binding was unimpaired. These data are inconsistent with the prevailing models and point to discrimination mechanisms that are likely to act at a chromosomal level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.