ArticleGenetics1999
Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Genetic analysis of IFNG-AS1 implicates opposite effects to Leishmania guyanensis-cutaneous leishmaniasis: rs4913269 confers protection while rs7134599 enhances susceptibility and correlates with high plasma IL-4 and IL-10 levels.PLoS neglected tropical diseases · 2025Article
- Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases.Neural regeneration research · 2023Review
- Genetic and immunological contributors to virus-induced paralysis.Brain, behavior, & immunity - health · 2021Article
- Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions.International journal of molecular sciences · 2021Article
- The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.Molecular cell · 2019Article
- Gene regulation in the immune system by long noncoding RNAs.Nature immunology · 2017Review
- Saffold virus, an emerging human cardiovirus.Reviews in medical virology · 2017Review
- Roles of LncRNAs in Viral Infections.Frontiers in cellular and infection microbiology · 2017Review
- Long non-coding RNAs: Mechanism of action and functional utility.Non-coding RNA research · 2016Review
- The Pathogenesis of Saffold Virus in AG129 Mice and the Effects of Its Truncated L Protein in the Central Nervous System.Viruses · 2016Article
- Long noncoding RNAs in diseases of aging.Biochimica et biophysica acta · 2016Review
- Individuality and variation of personal regulomes in primary human T cells.Cell systems · 2015Article
- Article
- Long non-coding RNAs (lncRNAs) and viral infections.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2013Article
- Article
- Association studies in outbred mice in a new era of full-genome sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- IRF3 polymorphisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages.Virology · 2011Article
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
- Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theiler's virus persistently infects the white matter of the spinal cord in susceptible strains of mice. This infection is associated with inflammation and primary demyelination and is studied as a model of multiple sclerosis. The H-2D gene is the major gene controlling viral persistence. However, the SJL/J strain is more susceptible than predicted by its H-2(s) haplotype. An (SJL/J x B10. S)F1 x B10.S backcross was analyzed, and one quantitative trait locus (QTL) was located in the telomeric region of chromosome 10 close to the Ifng locus. Another one was tentatively mapped to the telomeric region of chromosome 18, close to the Mbp locus. We now report the study of 14 congenic lines that carry different segments of these two chromosomes. Although the presence of a QTL on chromosome 18 was not confirmed, two loci controlling viral persistence were identified on chromosome 10 and named Tmevp2 and Tmevp3. Furthermore, the Ifng gene was excluded from the regions containing Tmevp2 and Tmevp3. Analysis of the mode of inheritance of Tmevp2 and Tmevp3 identified an effect of sex, with males being more infected than females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.