ArticleGenetics1999
Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity.PLoS biology · 2025Article
- Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1.Current genetics · 2023Review
- Molecular and Developmental Signatures of Genital Size Macro-Evolution in Bugs.Molecular biology and evolution · 2022Article
- Histone 3 lysine 4 monomethylation supports activation of transcription in S. cerevisiae during nutrient stress.Current genetics · 2022Article
- Why are so many MLL lysine methyltransferases required for normal mammalian development?Cellular and molecular life sciences : CMLS · 2019Review
- Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila.Scientific reports · 2018Article
- Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon.Frontiers in molecular neuroscience · 2017Article
- Stuxnet Facilitates the Degradation of Polycomb Protein during Development.Developmental cell · 2016Article
- Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration.Development (Cambridge, England) · 2015Article
- A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.Journal of molecular biology · 2014Article
- Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing.Development (Cambridge, England) · 2014Article
- HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.The Journal of clinical investigation · 2013Article
- Histone H3 lysine 4 (H3K4) methylation in development and differentiation.Developmental biology · 2010Review
- Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.Development (Cambridge, England) · 2009Article
- Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.Genes & development · 2006Article
- A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes.Molecular and cellular biology · 2005Article
- Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.Oncogene · 2004Article
- Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila.EMBO reports · 2003Article
- A homeotic mutation in the trithorax SET domain impedes histone binding.Genes & development · 2001Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
trithorax (trx) encodes chromosome-binding proteins required throughout embryogenesis and imaginal development for tissue- and cell-specific levels of transcription of many genes including homeotic genes of the ANT-C and BX-C. trx encodes two protein isoforms that contain conserved motifs including a C-terminal SET domain, central PHD fingers, an N-terminal DNA-binding homology, and two short motifs also found in the TRX human homologue, ALL1. As a first step to characterizing specific developmental functions of TRX, I examined phenotypes of 420 combinations of 21 trx alleles. Among these are 8 hypomorphic alleles that are sufficient for embryogenesis but provide different levels of trx function at homeotic genes in imaginal cells. One allele alters the N terminus of TRX, which severely impairs larval and imaginal growth. Hypomorphic alleles that alter different regions of TRX equivalently reduce function at affected genes, suggesting TRX interacts with common factors at different target genes. All hypomorphic alleles examined complement one another, suggesting cooperative TRX function at target genes. Comparative effects of hypomorphic genotypes support previous findings that TRX has tissue-specific interactions with other factors at each target gene. Some hypomorphic genotypes also produce phenotypes that suggest TRX may be a component of signal transduction pathways that provide tissue- and cell-specific levels of target gene transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.