ArticleGenetics1999
Transgenic inhibitors identify two roles for protein kinase A in Drosophila development.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- PKA restricts ERK signaling in learning and memory Kenyon cell neurons.Cellular signalling · 2025Article
- The regulation of carnitine palmitoyltransferase 1 (Biochemistry and biophysics reports · 2024Article
- Use-Dependent, Untapped Dual Kinase Signaling Localized in Brain Learning Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Activation of cyclic AMP signaling pathway in dopaminergic neurons rescues locomotion defects in a Drosophila larval model of Parkinson's disease.Brain research · 2024Article
- Review
- FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.Cell reports · 2020Article
- Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry.Neurobiology of disease · 2019Article
- Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.Human molecular genetics · 2016Article
- Article
- Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.PLoS genetics · 2013Article
- Integration of taste and calorie sensing in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Acute inhibition of PKA activity at old ages ameliorates age-related memory impairment in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A G-protein-coupled neuropeptide Y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The octopamine receptor OAMB mediates ovulation via Ca2+/calmodulin-dependent protein kinase II in the Drosophila oviduct epithelium.PloS one · 2009Article
- Axonal injury and regeneration in the adult brain of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Tissue remodeling during maturation of the Drosophila wing.Developmental biology · 2007Article
- Anthrax lethal factor and edema factor act on conserved targets in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling.Genetics · 2004Article
- Genetic modifiers of tauopathy in Drosophila.Genetics · 2003Article
- Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We have initiated an analysis of protein kinase A (PKA) in Drosophila using transgenic techniques to modulate PKA activity in specific tissues during development. We have constructed GAL4/UAS-regulated transgenes in active and mutant forms that encode PKAc, the catalytic subunit of PKA, and PKI(1-31), a competitive inhibitor of PKAc. We present evidence that the wild-type transgenes are active and summarize the phenotypes produced by a number of GAL4 enhancer-detector strains. We compare the effects of transgenes encoding PKI(1-31) with those encoding PKAr*, a mutant regulatory subunit that constitutively inhibits PKAc because of its inability to bind cyclic AMP. Both inhibitors block larval growth, but only PKAr* alters pattern formation by activating the Hedgehog signaling pathway. Therefore, transgenic PKI(1-31) should provide a tool to investigate the role of PKAc in larval growth regulation without concomitant changes in pattern formation. The different effects of PKI(1-31) and PKAr* suggest two distinct roles, cytoplasmic and nuclear, for PKAc in Hedgehog signal transduction. Alternatively, PKAr* may target proteins other than PKAc, suggesting a role for free PKAr in signal transduction, a role inhibited by PKAc in reversal of the classical relationship of these subunits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.