ArticleGenetics1999
Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.Genes · 2021Article
- Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila.Scientific reports · 2021Article
- MAPCap allows high-resolution detection and differential expression analysis of transcription start sites.Nature communications · 2019Article
- Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains.Epigenetics & chromatin · 2018Article
- Dosage-Dependent Expression Variation Suppressed on theG3 (Bethesda, Md.) · 2018Article
- Male-Killing Spiroplasma Alters Behavior of the Dosage Compensation Complex during Drosophila melanogaster Embryogenesis.Current biology : CB · 2016Article
- Facts and artifacts in studies of gene expression in aneuploids and sex chromosomes.Chromosoma · 2014Review
- Male X-linked genes in Drosophila melanogaster are compensated independently of the Male-Specific Lethal complex.Epigenetics & chromatin · 2013Article
- Dosage compensation and inverse effects in triple X metafemales of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Male-specific lethal complex in Drosophila counteracts histone acetylation and does not mediate dosage compensation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Autoregulation of the Drosophila Noncoding roX1 RNA Gene.PLoS genetics · 2012Article
- Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila.BMC molecular biology · 2010Article
- An evolutionary consequence of dosage compensation on Drosophila melanogaster female X-chromatin structure?BMC genomics · 2010Article
- Multiple invasions of Gypsy and Micropia retroelements in genus Zaprionus and melanogaster subgroup of the genus Drosophila.BMC evolutionary biology · 2009Article
- Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.Nature structural & molecular biology · 2009Article
- Drosophila dosage compensation: a complex voyage to the X chromosome.Development (Cambridge, England) · 2009Review
- X chromosomal regulation in flies: when less is more.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Studies on the short range spreading of the male specific lethal (MSL) complex on the X chromosome in Drosophila.Cytogenetic and genome research · 2009Article
- Interaction study of the male specific lethal (MSL) complex and trans-acting dosage effects in metafemales of Drosophila melanogaster.Cytogenetic and genome research · 2009Article
- LTR retrotransposons and the evolution of dosage compensation in Drosophila.BMC molecular biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunostaining of chromosomes shows that the male-specific lethal (MSL) proteins are associated with all female chromosomes at a low level but are sequestered to the X chromosome in males. Histone-4 Lys-16 acetylation follows a similar pattern in normal males and females, being higher on the X and lower on the autosomes in males than in females. However, the staining pattern of acetylation and the mof gene product, a putative histone acetylase, in msl mutant males returns to a uniform genome-wide distribution as found in females. Gene expression on the autosomes correlates with the level of histone-4 acetylation. With minor exceptions, the expression levels of X-linked genes are maintained with either an increase or decrease of acetylation, suggesting that the MSL complex renders gene activity unresponsive to H4Lys16 acetylation. Evidence was also found for the presence of nucleation sites for association of the MSL proteins with the X chromosome rather than individual gene binding sequences. We suggest that sequestration of the MSL proteins occurs in males to nullify on the autosomes and maintain on the X, an inverse effect produced by negatively acting dosage-dependent regulatory genes as a consequence of the evolution of the X/Y sex chromosomal system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.