ArticleGenetics1999
Coordination of the initiation of recombination and the reductional division in meiosis in Saccharomyces cerevisiae.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Heat stress reveals a specialized variant of the pachytene checkpoint in meiosis of Arabidopsis thaliana.The Plant cell · 2022Article
- Caught in the Act: Live-Cell Imaging of Plant Meiosis.Frontiers in plant science · 2021Review
- Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe.Genetics · 2008Article
- The signal from the initiation of meiotic recombination to the first division of meiosis.Eukaryotic cell · 2004Article
- Meiotic double-strand breaks at the interface of chromosome movement, chromosome remodeling, and reductional division.Genes & development · 2003Article
- Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p.Molecular and cellular biology · 2003Article
- The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast.Genetics · 2003Article
- Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae.Genetics · 2003Article
- Close, stable homolog juxtaposition during meiosis in budding yeast is dependent on meiotic recombination, occurs independently of synapsis, and is distinct from DSB-independent pairing contacts.Genes & development · 2002Article
- Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae.Genetics · 2002Article
- Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae.Genetics · 2001Article
- Characterization of rec7, an early meiotic recombination gene in Schizosaccharomyces pombe.Genetics · 2001Article
- Recombination can partially substitute for SPO13 in regulating meiosis I in budding yeast.Genetics · 2000Article
- Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p.Genes & development · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Early exchange (EE) genes are required for the initiation of meiotic recombination in Saccharomyces cerevisiae. Cells with mutations in several EE genes undergo an earlier reductional division (MI), which suggests that the initiation of meiotic recombination is involved in determining proper timing of the division. The different effects of null mutations on the timing of reductional division allow EE genes to be assorted into three classes: mutations in RAD50 or REC102 that confer a very early reductional division; mutations in REC104 or REC114 that confer a division earlier than that of wild-type (WT) cells, but later than that of mutants of the first class; and mutations in MEI4 that do not significantly alter the timing of MI. The very early mutations are epistatic to mutations in the other two classes. We propose a model that accounts for the epistatic relationships and the communication between recombination initiation and the first division. Data in this article indicate that double-strand breaks (DSBs) are not the signal for the normal delay of reductional division; these experiments also confirm that MEI4 is required for the formation of meiotic DSBs. Finally, if a DSB is provided by the HO endonuclease, recombination can occur in the absence of MEI4 and REC104.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.