ArticleGenetics1999
Maximal stimulation of meiotic recombination by a yeast transcription factor requires the transcription activation domain and a DNA-binding domain.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Expanding the genetic toolbox for Cutaneotrichosporon oleaginosus employing newly identified promoters and a novel antibiotic resistance marker.BMC biotechnology · 2023Article
- Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication.PLoS genetics · 2015Article
- New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination.Nucleic acids research · 2012Review
- Genomic signatures of germline gene expression.Genome research · 2010Article
- A positive but complex association between meiotic double-strand break hotspots and open chromatin in Saccharomyces cerevisiae.Genome research · 2009Article
- Genome-wide analyses of recombination prone regions predict role of DNA structural motif in recombination.PloS one · 2009Article
- Article
- Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response.Nucleic acids research · 2008Article
- Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination.Nucleic acids research · 2008Article
- Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe.Genetics · 2005Article
- Article
- SCH9, a putative protein kinase from Saccharomyces cerevisiae, affects HOT1-stimulated recombination.Molecular genetics and genomics : MGG · 2004Article
- Patterns of heteroduplex formation associated with the initiation of meiotic recombination in the yeast Saccharomyces cerevisiae.Genetics · 2003Article
- RAD1 controls the meiotic expansion of the human HRAS1 minisatellite in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- Meiotic recombination frequencies are affected by nutritional states in Saccharomycescerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Control of meiotic recombination and gene expression in yeast by a simple repetitive DNA sequence that excludes nucleosomes.Molecular and cellular biology · 1999Article
- Chromatin opening and transactivator potentiation by RAP1 in Saccharomyces cerevisiae.Molecular and cellular biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The DNA sequences located upstream of the yeast HIS4 represent a very strong meiotic recombination hotspot. Although the activity of this hotspot requires the transcription activator Rap1p, the level of HIS4 transcription is not directly related to the level of recombination. We find that the recombination-stimulating activity of Rap1p requires the transcription activation domain of the protein. We show that a hybrid protein with the Gal4p DNA-binding domain and the Rap1p activation domain can stimulate recombination in a strain in which Gal4p-binding sites are inserted upstream of HIS4. In addition, we find recombination hotspot activity associated with the Gal4p DNA-binding sites that is independent of known transcription factors. We suggest that yeast cells have two types of recombination hotspots, alpha (transcription factor dependent) and beta (transcription factor independent).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.