ArticleGenetics1999
Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Evidence that DNA polymerase δ proofreads errors made by DNA polymerase α across the Saccharomyces cerevisiae nuclear genome.DNA repair · 2024Article
- Polymorphism ofInternational journal of molecular sciences · 2023Article
- The inner side of yeast PCNA contributes to genome stability by mediating interactions with Rad18 and the replicative DNA polymerase δ.Scientific reports · 2022Article
- Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro.Nucleic acids research · 2017Article
- Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.DNA repair · 2017Review
- Mechanisms of glycosylase induced genomic instability.PloS one · 2017Article
- Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.Frontiers in genetics · 2017Article
- Eukaryotic genome instability in light of asymmetric DNA replication.Critical reviews in biochemistry and molecular biology · 2016Review
- DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae.Mutagenesis · 2015Article
- Volatility of Mutator Phenotypes at Single Cell Resolution.PLoS genetics · 2015Article
- Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans.PLoS genetics · 2015Article
- A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading.Cancer research · 2014Article
- Replicative DNA polymerase mutations in cancer.Current opinion in genetics & development · 2014Review
- Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.PLoS genetics · 2013Article
- Role of DNA polymerases in repeat-mediated genome instability.Cell reports · 2012Article
- Antimutator variants of DNA polymerases.Critical reviews in biochemistry and molecular biology · 2011Review
- Mutator suppression and escape from replication error-induced extinction in yeast.PLoS genetics · 2011Article
- Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.PLoS genetics · 2010Article
- DNA replication fidelity and cancer.Seminars in cancer biology · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Base selectivity, proofreading, and postreplication mismatch repair are important for replication fidelity. Because proofreading plays an important role in error correction, we have investigated factors that influence its impact in the yeast Saccharomyces cerevisiae. We have utilized a sensitive mutation detection system based on homonucleotide runs of 4 to 14 bases to examine the impact of DNA polymerase delta proofreading on mutation avoidance. The contribution of DNA polymerase delta proofreading on error avoidance was found to be similar to that of DNA polymerase epsilon proofreading in short homonucleotide runs (A4 and A5) but much greater than the contribution of DNA polymerase epsilon proofreading in longer runs. We have identified an intraprotein interaction affecting mutation prevention that results from mutations in the replication and the proofreading regions, resulting in an antimutator phenotype relative to a proofreading defect. Finally, a diploid strain with a defect in DNA polymerase delta proofreading exhibits a higher mutation rate than a haploid strain. We suggest that in the diploid population of proofreading defective cells there exists a transiently hypermutable fraction that would be inviable if cells were haploids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.