ArticleGenetics1999
Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Selection and Plasmid Transfer Underlie Adaptive Mutation inGenetics · 2018Article
- Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli.Genetics · 2015Article
- Article
- Stress-Induced Mutagenesis.EcoSal Plus · 2012Article
- What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Journal of molecular microbiology and biotechnology · 2011Article
- Amplification of lac cannot account for adaptive mutation to Lac+ in Escherichia coli.Journal of bacteriology · 2007Article
- Article
- Stress responses and genetic variation in bacteria.Mutation research · 2005Review
- Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms.PLoS biology · 2004Article
- Rebuttal: growth under selection stimulates Lac(+) reversion (Roth and Andersson).Journal of bacteriology · 2004Article
- Adaptive mutation in Escherichia coli.Journal of bacteriology · 2004Article
- Isolation and characterization of a generalized transducing phage for Pseudomonas aeruginosa strains PAO1 and PA14.Journal of bacteriology · 2004Article
- Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli.Molecular microbiology · 2003Article
- Induction of a DNA nickase in the presence of its target site stimulates adaptive mutation in Escherichia coli.Journal of bacteriology · 2002Article
- Article
- The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions.Journal of bacteriology · 2001Article
- Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination.Genetics · 2000Article
- Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.Journal of bacteriology · 2000Article
- Adaptive mutation in Escherichia coli.Cold Spring Harbor symposia on quantitative biology · 2000Review
- Mechanisms of mutation in nondividing cells. Insights from the study of adaptive mutation in Escherichia coli.Annals of the New York Academy of Sciences · 1999Review
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive mutation has been studied extensively in FC40, a strain of Escherichia coli that cannot metabolize lactose (Lac-) because of a frameshift mutation affecting the lacZ gene on its episome. recD mutants of FC40, in which the exonuclease activity of RecBCD (ExoV) is abolished but its helicase activity is retained, have an increased rate of adaptive mutation. The results presented here show that, in several respects, adaptive mutation to Lac+ involves different mechanisms in recD mutant cells than in wild-type cells. About half of the apparent increase in the adaptive mutation rate of recD mutant cells is due to a RecA-dependent increase in episomal copy number and to growth of the Lac- cells on the lactose plates. The remaining increase appears to be due to continued replication of the episome, with the extra copies being degraded or passed to recD+ recipients. In addition, the increase in adaptive mutation rate in recD mutant cells is (i) dependent on activities of the single-stranded exonucleases, RecJ and ExoI, which are not required for (in fact, slightly inhibit) adaptive mutation in wild-type cells, and (ii) enhanced by RecG, which opposes adaptive mutation in wild-type cells.
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