ArticleJournal of neuro-oncology1999
Comparative genomic hybridization analysis of genetic alterations associated with malignant progression of meningioma.
Article in Journal of neuro-oncology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Seq-ing answers: exploring meningioma biology utilizing bulk RNA-seq-based reference landscapes.Frontiers in oncology · 2025Review
- Integration of molecular pathology with histopathology to accurately evaluate the biological behaviour of WHO grade 2 meningiomas and patient prognosis.Journal of neuro-oncology · 2022Article
- Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma.Acta neuropathologica · 2017Article
- Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma.Brain pathology (Zurich, Switzerland) · 2015Article
- Brain tumors: Special characters for research and banking.Advanced biomedical research · 2015Review
- Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Molecular and genetic profiles of radiographically defined de novo meningiomas.Journal of neuro-oncology · 2012Article
- Gain of chromosome arm 1q in atypical meningioma correlates with shorter progression-free survival.Neuropathology and applied neurobiology · 2012Article
- Common molecular cytogenetic pathway in papillary tumors of the pineal region (PTPR).Brain pathology (Zurich, Switzerland) · 2011Article
- Tumor grade-related NDRG2 gene expression in primary and recurrent intracranial meningiomas.Journal of neuro-oncology · 2011Article
- Differential expression profiling analyses identifies downregulation of 1p, 6q, and 14q genes and overexpression of 6p histone cluster 1 genes as markers of recurrence in meningiomas.Neuro-oncology · 2010Article
- A review of malignant meningiomas: diagnosis, characteristics, and treatment.Journal of neuro-oncology · 2010Review
- Genomic landscape of meningiomas.Brain pathology (Zurich, Switzerland) · 2010Article
- Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome.Journal of neuropathology and experimental neurology · 2009Article
- Early malignant transformation of a petroclival meningothelial meningioma.Neurosurgical review · 2009Article
- Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.Neuro-oncology · 2009Article
- Methylation-specific multiplex ligation-dependent probe amplification in meningiomas.Journal of neuro-oncology · 2008Article
- Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region.Journal of neuro-oncology · 2007Article
- Molecular pathogenesis of meningiomas.Journal of neuro-oncology · 2004Review
- Brain tumours: classification and genes.Journal of neurology, neurosurgery, and psychiatry · 2004Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about genetic alterations during malignant progression of meningioma. We used comparative genomic hybridization (CGH) in 20 patients (13 with typical, 4 with atypical and 3 with anaplastic meningiomas) to investigate the genetic pathway underlying the development of meningioma. Typical meningiomas displayed only a few genetic changes such as monosomy 22. Anaplastic meningiomas manifested more aberrations than typical meningiomas, frequently exhibiting losses of 1p, 2p, 6q, chromosome 10 and 14q, and gain of 20q, in addition to monosomy 22. The average number of alteration sites in each patient with typical meningioma was significantly less than those in each patient with atypical (p < 0.01) and with anaplastic meningioma (p < 0.05). Anaplastic meningiomas showed the chromosomal changes seen in atypical meningiomas together with other aberrations. These CGH findings suggest that losses of 1p, 2p, 6q, chromosome 10 and 14q, and gain of 20q are genetic changes implicated in the malignant progression of meningioma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.