ArticleBMJ (Clinical research ed.)1999
Pertussis vaccination and wheezing illnesses in young children: prospective cohort study. The Longitudinal Study of Pregnancy and Childhood Team.
Article in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Whole-cell pertussis vaccine in early infancy for the prevention of allergy in children.The Cochrane database of systematic reviews · 2021Pooled it
- Update on Selected Adverse Events of Concern Following Immunization With Acellular Pertussis Vaccines, a Narrative Review.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- COVID-19 in children: Could pertussis vaccine play the protective role?Medical hypotheses · 2020Article
- Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children.Postepy dermatologii i alergologii · 2018Article
- Alcohol Use in Adolescence and Later Working Memory: Findings From a Large Population-Based Birth Cohort.Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Article
- A new socioeconomic status measure for vaccine research in children using individual housing data: a population-based case-control study.BMC public health · 2016Article
- Article
- The Paris prospective birth cohort study: which design and who participates?European journal of epidemiology · 2007Article
- Too clean, or not too clean: the hygiene hypothesis and home hygiene.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2006Review
- Acellular pertussis vaccine protects against exacerbation of allergic asthma due to Bordetella pertussis in a murine model.Clinical and diagnostic laboratory immunology · 2005Article
- Vaccination and allergic disease: a birth cohort study.American journal of public health · 2004Article
- Pertussis vaccination in infancy and asthma or allergy in later childhood: birth cohort study.BMJ (Clinical research ed.) · 2004Article
- Is the hygiene hypothesis an example of hormesis?Nonlinearity in biology, toxicology, medicine · 2003Article
- Does a higher number of siblings protect against the development of allergy and asthma? A review.Journal of epidemiology and community health · 2002Review
- Immunization and symptoms of atopic disease in children: results from the International Study of Asthma and Allergies in Childhood.American journal of public health · 2001Article
- Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens.Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the relation between pertussis vaccination and the prevalence of wheezing illnesses in young children.
designProspective cohort study.
settingThree former health districts comprising Avon Health Authority. SUBJECTS: 9444 of 14 138 children enrolled in the Avon longitudinal study of pregnancy and childhood and for whom data on wheezing symptoms, vaccination status, and 15 environmental and biological variables were available.
main outcome measuresEpisodes of wheezing from birth to 6 months, 7-18 months, 19-30 months, and 31-42 months. These time periods were used to derive five categories of wheezing illness: early wheezing (not after 18 months); late onset wheezing (after 18 months); persistent wheezing (at every time period); recurrent wheezing (any combination of two or more episodes for each period); and intermittent wheezing (any combination of single episodes of reported wheezing). These categories were stratified according to parental self reported asthma or allergy.
resultsUnadjusted comparisons of the defined wheezing illnesses in vaccinated and non-vaccinated children showed no significant association between pertussis vaccination and any of the wheezing outcomes regardless of stratification for parental asthma or allergy. Wheeze was more common in non-vaccinated children at 18 months, and there was a tendency for late onset wheezing to be associated with non-vaccination in children whose parents did not have asthma, but this was not significant. After adjustment for environmental and biological variables, logistic regression analyses showed no significant increased relative risk for any of the wheezing outcomes in vaccinated children: early wheezing (0.99, 95% confidence interval 0.80 to 1.23), late onset wheezing (0.85, 0.69 to 1.05), persistent wheezing (0.91, 0.47 to 1.79), recurrent wheezing (0.96, 0.72 to 1.26), and intermittent wheezing (1.06, 0.81 to 1.37).
conclusionsNo evidence was found that pertussis vaccination increases the risk of wheezing illnesses in young children. Further follow up of this population with objective measurement of allergy and bronchial responsiveness is planned to confirm these observations.
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