ArticleProceedings of the National Academy of Sciences of the United States of America1999
Regulatory interaction of PRL1 WD protein with Arabidopsis SNF1-like protein kinases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed, 210 citations in OpenAlex.
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- Pleiotropic regulatory locus 1 maintains actin cytoskeleton integrity and cellular homeostasis to enable Arabidopsis root growth.iScience · 2024Article
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.Science advances · 2024Article
- DOMAIN OF UNKNOWN FUNCTION581-9 negatively regulates SnRK1 kinase activity.Plant physiology · 2024Article
- GRIK phosphorylates and activates KIN10 which also promotes its degradation.Frontiers in plant science · 2024Article
- Identification and characteristics of SnRK genes and cold stress-induced expression profiles in Liriodendron chinense.BMC genomics · 2022Article
- Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulatesScience signaling · 2021Article
- Lessons from Comparison of Hypoxia Signaling in Plants and Mammals.Plants (Basel, Switzerland) · 2021Review
- MOS1 Negatively Regulates Sugar Responses and Anthocyanin Biosynthesis in Arabidopsis.International journal of molecular sciences · 2020Article
- Default Activation and Nuclear Translocation of the Plant Cellular Energy Sensor SnRK1 Regulate Metabolic Stress Responses and Development.The Plant cell · 2019Article
- Alternative Carbon Sources for Isoprene Emission.Trends in plant science · 2018Review
- Trehalose 6-Phosphate Positively Regulates Fatty Acid Synthesis by Stabilizing WRINKLED1.The Plant cell · 2018Article
- AKIN10 activity as a cellular link between metabolism and circadian-clock entrainment in Arabidopsis thaliana.Plant signaling & behavior · 2018Article
- Rice Leaf Angle and Grain Size Are Affected by the OsBUL1 Transcriptional Activator Complex.Plant physiology · 2017Article
- The Arabidopsis SR45 Splicing Factor, a Negative Regulator of Sugar Signaling, Modulates SNF1-Related Protein Kinase 1 Stability.The Plant cell · 2016Article
- SUMOylation represses SnRK1 signaling in Arabidopsis.The Plant journal : for cell and molecular biology · 2016Article
- Holophytochrome-Interacting Proteins in Physcomitrella: Putative Actors in Phytochrome Cytoplasmic Signaling.Frontiers in plant science · 2016Article
- The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control.Cold Spring Harbor perspectives in biology · 2015Review
- TANG1, Encoding a Symplekin_C Domain-Contained Protein, Influences Sugar Responses in Arabidopsis.Plant physiology · 2015Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation of the PRL1 gene, encoding a regulatory WD protein, results in glucose hypersensitivity and derepression of glucose-regulated genes in Arabidopsis. The yeast SNF1 protein kinase, a key regulator of glucose signaling, and Arabidopsis SNF1 homologs AKIN10 and AKIN11, which can complement the Deltasnf1 mutation, were found to interact with an N-terminal domain of the PRL1 protein in the two-hybrid system and in vitro. AKIN10 and AKIN11 suppress the yeast Deltasnf4 mutation and interact with the SNF4p-activating subunit of SNF1. PRL1 and SNF4 bind independently to adjacent C-terminal domains of AKIN10 and AKIN11, and these protein interactions are negatively regulated by glucose in yeast. AKIN10 and AKIN11, purified in fusion with glutathione S-transferase, undergo autophosphorylation and phosphorylate a peptide of sucrose phosphate synthase in vitro. The sucrose phosphate synthase-peptide kinase activity of AKIN complexes detected by immunoprecipitation is stimulated by sucrose in light-grown Arabidopsis plants. In comparison with wild type, the activation level of AKIN immunocomplexes is higher in the prl1 mutant, suggesting that PRL1 is a negative regulator of Arabidopsis SNF1 homologs. This conclusion is supported by the observation that PRL1 is an inhibitor of AKIN10 and AKIN11 in vitro.
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