ArticleProceedings of the National Academy of Sciences of the United States of America1999
Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed.
- Synthesis and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological Recognition.ACS medicinal chemistry letters · 2026Article
- The lipid language of tuberculosis:mBio · 2026Review
- Precision native polysaccharides from living polymerization of anhydrosugars.Nature chemistry · 2023Article
- Review
- Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases.Clinical microbiology reviews · 2021Review
- The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system.The Biochemical journal · 2020Review
- NKT cells in liver diseases.Frontiers of medicine · 2018Review
- Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections.Frontiers in immunology · 2018Review
- Emerging Concepts of Adaptive Immunity in Leprosy.Frontiers in immunology · 2018Review
- Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.PLoS pathogens · 2017Article
- Tailored design of NKT-stimulatory glycolipids for polarization of immune responses.Journal of biomedical science · 2017Review
- Development of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen.Journal of translational medicine · 2015Article
- Interleukins 15 and 12 in combination expand the selective loss of natural killer T cells in HIV infection in vitro.Clinical and experimental medicine · 2015Article
- Role of Group 1 CD1-Restricted T Cells in Infectious Disease.Frontiers in immunology · 2015Review
- CD1d-restricted NKT cells modulate placental and uterine leukocyte populations during chlamydial infection in mice.Microbes and infection · 2013Article
- The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?Clinical & developmental immunology · 2012Review
- Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway.PLoS pathogens · 2012Article
- Article
- Analysis of invariant natural killer T cells in human paracoccidioidomycosis.Mycopathologia · 2011Article
- Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation.Infection and immunity · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice injected with deproteinized cell walls prepared from the strain H37rv of Mycobacterium tuberculosis develop a granuloma-like lesion in which NKT cells are predominant. NKT cells play a primary role in the granulomatous response, because the latter does not occur in Jalpha281(-/-) mice, which miss NKT cells. The glycolipidic fraction of the cell walls is responsible for the recruitment of NKT cells; the recruiting activity is associated with fractions containing phosphatidylinositolmannosides. These results define a powerful experimental set up for studying the in vivo induction of NKT cell responses to microbial components.
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