ArticleProceedings of the National Academy of Sciences of the United States of America1999
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 141 citations in OpenAlex.
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- Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families.Scientific reports · 2017Article
- Olfactory dysfunction and quality of life in patients with transfusion-dependent thalassemia.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Evolution of hemoglobin and its genes.Cold Spring Harbor perspectives in medicine · 2012Article
- An RNA architectural locus control region involved in Dscam mutually exclusive splicing.Nature communications · 2012Article
- Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs.BMC genomics · 2011Article
- Globin gene structure in a reptile supports the transpositional model for amniote α- and β-globin gene evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Genomic organization and gene expression of the multiple globins in Atlantic cod: conservation of globin-flanking genes in chordates infers the origin of the vertebrate globin clusters.BMC evolutionary biology · 2010Article
- Appearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus.Journal of molecular endocrinology · 2010Article
- Lineage-specific patterns of functional diversification in the alpha- and beta-globin gene families of tetrapod vertebrates.Molecular biology and evolution · 2010Article
- Cell type specificity of chromatin organization mediated by CTCF and cohesin.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A census of human transcription factors: function, expression and evolution.Nature reviews. Genetics · 2009Review
- Article
- Three-dimensional positioning of genes in mouse cell nuclei.Chromosoma · 2008Article
- Epigenetics of beta-globin gene regulation.Mutation research · 2008Review
- Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals.BMC biology · 2008Article
Corrections and comments
- Erratum issuedvon Doorninck JH [corrected to van Doorninck JH]
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
In mouse and human, the beta-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences of the mouse and human beta-globin LCRs are homologous, indicating conservation of an essential function in beta-globin gene regulation. We have sequenced regions flanking the beta-globin locus in both mouse and human and found that homology associated with the LCR is more extensive than previously known, making up a conserved block of approximately 40 kb. In addition, we have identified DNaseI-hypersensitive sites within the newly sequenced regions in both mouse and human, and these structural features also are conserved. Finally, we have found that both mouse and human beta-globin loci are embedded within an array of odorant receptor genes that are expressed in olfactory epithelium, and we also identify an olfactory receptor gene located 3' of the beta-globin locus in chicken. The data demonstrate an evolutionarily conserved genomic organization for the beta-globin locus and suggest a possible role for the beta-globin LCR in control of expression of these odorant receptor genes and/or the presence of mechanisms to separate regulatory signals in different tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.