ArticleProceedings of the National Academy of Sciences of the United States of America1999
Hypermutation in derepressed operons of Escherichia coli K12.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Article
- Anaerobically Grown Escherichia coli Has an Enhanced Mutation Rate and Distinct Mutational Spectra.PLoS genetics · 2017Article
- Inheritance is where physiology meets evolution.The Journal of physiology · 2014Review
- Transcription-associated mutagenesis.Annual review of genetics · 2014Review
- High levels of transcription stimulate transversions at GC base pairs in yeast.Environmental and molecular mutagenesis · 2013Article
- Stress-Induced Mutagenesis.EcoSal Plus · 2012Article
- Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
- The roles of transcription and genotoxins underlying p53 mutagenesis in vivo.Carcinogenesis · 2011Article
- Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Transposon-mediated adaptive and directed mutations and their potential evolutionary benefits.Journal of molecular microbiology and biotechnology · 2011Review
- What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Journal of molecular microbiology and biotechnology · 2011Article
- The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli.Molecular microbiology · 2010Article
- Co-orientation of replication and transcription preserves genome integrity.PLoS genetics · 2010Article
- Gene duplication and hypermutation of the pathogen Resistance gene SNC1 in the Arabidopsis bal variant.Genetics · 2009Article
- A mechanism of transposon-mediated directed mutation.Molecular microbiology · 2009Article
- Genomic mutation rates: what high-throughput methods can tell us.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Review
- DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli.Genetics · 2009Article
- Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.PLoS genetics · 2008Article
- A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article presents evidence that starvation for leucine in an Escherichia coli auxotroph triggers metabolic activities that specifically target the leu operon for derepression, increased rates of transcription, and mutation. Derepression of the leu operon was a prerequisite for its activation by the signal nucleotide, guanosine tetraphosphate, which accumulates in response to nutritional stress (the stringent response). A quantitative correlation was established between leuB mRNA abundance and leuB- reversion rates. To further demonstrate that derepression increased mutation rates, the chromosomal leu operon was placed under the control of the inducible tac promoter. When the leu operon was induced by isopropyl-D-thiogalactoside, both leuB mRNA abundance and leuB- reversion rates increased. These investigations suggest that guanosine tetraphosphate may contribute as much as attenuation in regulating leu operon expression and that higher rates of mutation are specifically associated with the derepressed leu operon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.