ArticleProceedings of the National Academy of Sciences of the United States of America1999
The proapoptotic function of Drosophila Hid is conserved in mammalian cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 101 citations in OpenAlex.
- Microbiome Integrity Protects Against Glial-Mediated Tau and Amyloid Pathology Through Circadian and Autophagy Homeostasis.bioRxiv : the preprint server for biology · 2026Article
- AlphaFold3-based modeling uncovers the dynamic structural interface between full-length IAP antagonists and DIAP1 for apoptosis regulation in Drosophila.Cell communication and signaling : CCS · 2026Article
- Understanding Developmental Cell Death UsingCells · 2024Review
- miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model.Cell death & disease · 2024Article
- Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis inAutophagy reports · 2023Article
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- Regulation and coordination of the different DNA damage responses inFrontiers in cell and developmental biology · 2022Review
- Deep Conservation ofInsects · 2021Article
- Dally-like protein sequesters multiple Wnt ligands in the Drosophila germarium.Developmental biology · 2020Article
- Pro-Apoptotic Function Analysis of the Reaper Homologue IBM1 inInternational journal of molecular sciences · 2020Article
- Article
- Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system.FEBS letters · 2016Review
- Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals.Development (Cambridge, England) · 2016Article
- Hid arbitrates collective cell death in the Drosophila wing.Mechanisms of development · 2015Article
- Fruit flies in biomedical research.Genetics · 2015Article
- Regulation of Cell Death by IAPs and Their Antagonists.Current topics in developmental biology · 2015Review
- CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid.Cell reports · 2013Article
- Combinatorial use of translational co-factors for cell type-specific regulation during neuronal morphogenesis in Drosophila.Developmental biology · 2012Article
- Review
- Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.Cell death and differentiation · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three genes-reaper, grim, and hid-are crucial to the regulation of programmed cell death in Drosophila melanogaster. Mutations involving all three genes virtually abolish apoptosis during development, and homozygous hid mutants die as embryos with extensive defects in apoptosis. Although Hid is central to apoptosis in Drosophila, it has no mammalian homologue identified to date. We present evidence that expression of Drosophila Hid in mammalian cells induces apoptosis. This activity is subject to regulation by inhibitors of mammalian cell death. We show that the N terminus of Hid, which is a region of homology with Reaper and Grim, is essential for Hid's function in mammalian cells. We demonstrate that Hid is localized to the mitochondria via a hydrophobic region at its C terminus and functionally interacts with BclXL. This study shows that the function of Hid as a death inducer in Drosophila is conserved in mammalian cells and argues for the existence of a mammalian homologue of this critical regulator of apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.