ArticleProceedings of the National Academy of Sciences of the United States of America1999
Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The role of disorder in RNA binding affinity and specificity.Open biology · 2020Article
- Shep RNA-Binding Capacity Is Required for Antagonism ofG3 (Bethesda, Md.) · 2019Article
- Sampling Native-like Structures of RNA-Protein Complexes through Rosetta Folding and Docking.Structure (London, England : 1993) · 2019Article
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- A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.Genes & development · 2014Article
- The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA.Nucleic acids research · 2013Article
- Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology.Journal of biomolecular NMR · 2013Article
- The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.PloS one · 2011Article
- Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.PloS one · 2010Article
- Structural insights into TDP-43 in nucleic-acid binding and domain interactions.Nucleic acids research · 2009Article
- Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements.The journal of physical chemistry. B · 2008Article
- Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.Journal of molecular biology · 2008Article
- Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.Journal of proteome research · 2007Article
- Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif.Journal of molecular biology · 2007Article
- PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.Oncogene · 2005Article
- Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.The EMBO journal · 2004Article
- A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context.Development genes and evolution · 2004Article
- The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro.RNA (New York, N.Y.) · 2004Article
- The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element.Nucleic acids research · 2004Article
- A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA.The EMBO journal · 2003Article
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4 authors.
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Abstract
By binding specific RNA transcripts, the Sex-lethal protein (SXL) governs sexual differentiation and dosage compensation in Drosophila melanogaster. To investigate the basis for RNA binding specificity, we determined the crystal structure of the tandem RNA recognition motifs (RRMs) of SXL. Both RRMs adopt the canonical RRM fold, and the 10-residue, interdomain linker shows significant disorder. In contrast to the previously determined structure of the two-RRM fragment of heterogeneous nuclear ribonucleoprotein Al, SXL displays no interdomain contacts between RRMs. These results suggest that the SXL RRMs are flexibly tethered in solution, and RNA binding restricts the orientation of RRMs. Therefore, the observed specificity for single-stranded, U-rich sequences does not arise from a predefined, rigid architecture of the isolated SXL RRMs.
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