ArticleProceedings of the National Academy of Sciences of the United States of America1999
Transfer of plastid RNA-editing activity to novel sites suggests a critical role for spacing in editing-site recognition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Synthetic Pentatricopeptide Repeat Proteins: Building a Toolkit for Precise RNA Control.International journal of molecular sciences · 2025Review
- Review
- Identification of the chloroplast adenosine-to-inosine tRNA editing enzyme.RNA (New York, N.Y.) · 2009Article
- Post-transcriptional control of chloroplast gene expression.Gene regulation and systems biology · 2009Article
- Characteristics and prediction of RNA editing sites in transcripts of the Moss Takakia lepidozioides chloroplast.DNA research : an international journal for rapid publication of reports on genes and genomes · 2008Article
- Faithful editing of a tomato-specific mRNA editing site in transgenic tobacco chloroplasts.RNA (New York, N.Y.) · 2008Article
- Two RNA editing sites with cis-acting elements of moderate sequence identity are recognized by an identical site-recognition protein in tobacco chloroplasts.Nucleic acids research · 2008Article
- Identification of a sequence motif critical for editing of a tobacco chloroplast transcript.RNA (New York, N.Y.) · 2007Article
- Constancy of organellar genome copy numbers during leaf development and senescence in higher plants.Molecular genetics and genomics : MGG · 2006Article
- Sequence elements critical for efficient RNA editing of a tobacco chloroplast transcript in vivo and in vitro.Nucleic acids research · 2006Article
- Chloroplast RNA-binding proteins.Current genetics · 2003Review
- RNA editing in hornwort chloroplasts makes more than half the genes functional.Nucleic acids research · 2003Article
- Recognition of RNA editing sites is directed by unique proteins in chloroplasts: biochemical identification of cis-acting elements and trans-acting factors involved in RNA editing in tobacco and pea chloroplasts.Molecular and cellular biology · 2002Article
- cis Recognition elements in plant mitochondrion RNA editing.Molecular and cellular biology · 2001Article
- A single alteration 20 nt 5' to an editing target inhibits chloroplast RNA editing in vivo.Nucleic acids research · 2001Article
- Involvement of a site-specific trans-acting factor and a common RNA-binding protein in the editing of chloroplast mRNAs: development of a chloroplast in vitro RNA editing system.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA editing in higher plant plastids alters mRNA sequences by C-to-U conversions at highly specific sites through an unknown mechanism. To elucidate how the cytidine residues to be edited are specifically recognized and distinguished from other cytidines in close proximity, we have changed in vivo the distances of two plastid RNA-editing sites from their essential upstream cis-acting sequence element. Analysis of RNA editing in transgenic chloroplasts revealed that reduction of this distance by 1 nt entirely abolishes RNA editing. Surprisingly, deletions or combinations of deletional and point mutations that shift a heterologous cytidine residue in the same distance from the upstream cis-element as the editing site in the wild type result in transfer of the RNA-editing activity to the heterologous cytidine whereas the wild-type site remains unedited. Our results suggest that the molecular identity of at least some editing sites in the chloroplast genome is defined by their distance from an essential upstream sequence element.
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Registered trials
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