ArticleProceedings of the National Academy of Sciences of the United States of America1999
The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Development of salinity tolerance in rice by constitutive-overexpression of genes involved in the regulation of programmed cell death.Frontiers in plant science · 2015Article
- Quantitative proteomics of Spodoptera frugiperda cells during growth and baculovirus infection.PloS one · 2011Article
- Evidence for caspase effects on release of cytochrome c and AIF in a model of ischemia in cortical neurons.Neuroscience letters · 2010Article
- Cellular stress responses: cell survival and cell death.International journal of cell biology · 2010Article
- Article
- Indian herb 'Sanjeevani' (Selaginella bryopteris) can promote growth and protect against heat shock and apoptotic activities of ultra violet and oxidative stress.Journal of biosciences · 2005Article
- Biochemical basis of the high resistance to oxidative stress in Dictyostelium discoideum.Journal of biosciences · 2003Article
- Host-pathogen interactions during apoptosis.Journal of biosciences · 2003Review
- Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts.Environmental health perspectives · 2002Article
- Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.Critical reviews in biochemistry and molecular biologyReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular imbalance in the levels of antioxidants and reactive oxygen species resulting in apoptosis is directly associated with a number of parasitic infections, aging, and several genetic and multifactorial diseases. The baculovirus AcNPV-encoded antiapoptotic p35 gene prevents apoptosis induced by a variety of apoptotic agents in different systems. We demonstrate the ability of the p35 gene to inhibit oxidative stress-induced apoptosis. In vitro cultured Spodoptera frugiperda (Sf9) insect cells infected with wild-type AcNPV carrying the antiapoptotic p35 gene did not undergo apoptosis when subjected to oxidative stress generated by the exogenous application of oxidants or in vivo generation of reactive oxygen species or on direct exposure of cells to UV radiations. An AcNPV mutant carrying a deletion of the p35 gene failed to arrest cell death. Transfection of cells with a recombinant plasmid containing the p35 gene under the transcriptional control of a stress promoter (Drosophila hsp70) was also able to rescue cells from oxidative stress-induced cell death, demonstrating the direct involvement of P35. ESR spin-trapping studies conducted in vitro and in vivo demonstrated that P35 functions directly as an antioxidant by mopping out free radicals and consequently prevents cell death by acting at an upstream step in the reactive oxygen species-mediated cell death pathway.
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