ReviewJournal of mammary gland biology and neoplasia1999
Progesterone signaling and mammary gland morphogenesis.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 68 citations in OpenAlex.
- Progesterone Regulation of Milk Fat Globule Size Is VLDL Dependent.Frontiers in endocrinology · 2020Article
- Review
- Psychosocial Stress Exposure Disrupts Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2018Article
- Association between body mass index and breast cancer intrinsic subtypes in Japanese women.Experimental and therapeutic medicine · 2012Article
- Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors.Hormones & cancer · 2012Article
- Juvenile hormone action through a defined enhancer motif to modulate ecdysteroid-activation of natural core promoters.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2012Article
- Article
- Impact of body mass index on breast cancer in accordance with the life-stage of women.Frontiers in oncology · 2012Article
- Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development.Molecular biology of the cell · 2004Article
- Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases.The American journal of pathology · 2003Article
- Id-1 is not expressed in the luminal epithelial cells of mammary glands.Breast cancer research : BCR · 2003Article
- Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.The American journal of pathology · 2002Article
- Impact of progesterone receptor on cell-fate decisions during mammary gland development.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Progesterone was identified as a mammogenic hormone several years ago but until now its precise role in mammary development has remained obscure. Recently with the generation of several transgenic mouse models and development of reagents for analysis of progesterone receptor expression, the role of progesterone signaling in mammary development is becoming more clear. The most significant observations to emerge from these studies are (1) progesterone receptors (PR) are present in a heterogeneous manner in the epithelial cells and undetectable in the surrounding fat pad; (2) they are essential for lobuloalveolar and not for ductal morphogenesis; (3) progesterone signaling through progesterone receptors, leading to lobuloalveolar development, is initiated in the epithelium and may occur through paracrine mechanisms; and (4) a regulated expression of the two isoforms of progesterone receptor is critical for maintaining appropriate responsiveness to progesterone and hence, epithelial cell replicative homeostasis. These studies also reveal that the consequences of progesterone signaling through progesterone receptor may depend on the cell context, cell-cell and cell-extracellular matrix interactions, the dynamics of PR turnover and the fate of PR positive cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.