ReviewJournal of mammary gland biology and neoplasia1999
Mammary epithelial stem cells: our current understanding.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 84 citations in OpenAlex.
- METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn).Journal of mammary gland biology and neoplasia · 2021Review
- Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression.Frontiers in cell and developmental biology · 2018Review
- Pathobiology of the 129:Stat1Breast cancer research : BCR · 2017Article
- The mammary cellular hierarchy and breast cancer.Cellular and molecular life sciences : CMLS · 2014Review
- Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution.Breast cancer research : BCR · 2013Article
- Mammary stem cell research in veterinary science: an update.Stem cells and development · 2013Review
- Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.Journal of cell science · 2012Article
- Determining mammosphere-forming potential: application of the limiting dilution analysis.Journal of mammary gland biology and neoplasia · 2012Review
- Mammary gland stem cells: more puzzles than explanations.Journal of biosciences · 2012Review
- Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Breast cancer risk from different mammography screening practices.Radiation research · 2010Article
- Article
- Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell.Journal of mammary gland biology and neoplasia · 2010Review
- The breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology.Environmental health perspectives · 2009Review
- Pregnancy and breast cancer: when they collide.Journal of mammary gland biology and neoplasia · 2009Review
- Expression of a putative stem cell marker, Musashi 1, in mammary glands of ewes.Journal of molecular histology · 2009Article
- Integrins in mammary-stem-cell biology and breast-cancer progression--a role in cancer stem cells?Journal of cell science · 2009Review
- Musashi1: a stem cell marker no longer in search of a function.Cell cycle (Georgetown, Tex.) · 2008Review
- Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens.Journal of mammary gland biology and neoplasia · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently been shown that the progeny from a single cell may comprise the epithelial population of a fully developed lactating mammary outgrowth in mice. Serial transplantation of epithelial fragments from this clonally derived gland demonstrates that the subsequently generated outgrowths are also comprised of progeny from the original antecedent. Similarly, genetic analysis of contiguous portions of individual human mammary ducts within the same breast indicates their clonal derivation. These observations support the concept that multipotent tissue-specific epithelial stem cells are present among the parenchymal cells of the mammary gland. Here, we present the developing evidence for the presence of stem cells in virtually every renewing mammalian tissue as well as some classically considered to consist only of differentiated cells. Further, we review the present morphologic and biologic evidence for stem cells and lineage-limited progenitor cells in human and rodent mammary epithelium. Although a number of selective markers are known for various lineage-limited hematopoietic cells and their progeny, our understanding of the biology of the precursor cells for mammary epithelium is just beginning. Our purpose here is to develop further interest in the clarification of these issues in the biology of the mammary gland.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.