ArticleDigestive diseases and sciences1999
Local and systemic liberation of proinflammatory cytokines in ulcerative colitis.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Transcript levels of different cytokines and chemokines correlate with clinical and endoscopic activity in ulcerative colitis.BMC gastroenterology · 2009Trial
- Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus nonresponders.World journal of gastroenterology · 2006Trial
- Modulation of the Epithelial-Immune Cell Crosstalk and Related Galectin Secretion by DP3-5 Galacto-Oligosaccharides and β-3'Galactosyllactose.Biomolecules · 2022Article
- IBS-Symptoms in IBD Patients-Manifestation of Concomitant or Different Entities.Journal of clinical medicine · 2020Review
- IBS and IBD - separate entities or on a spectrum?Nature reviews. Gastroenterology & hepatology · 2016Review
- Regulatory T cells in inflammatory bowel diseases and colorectal cancer.World journal of gastroenterology · 2012Review
- Critical role of nociceptor plasticity in chronic pain.Trends in neurosciences · 2009Review
- Distinct Methylation of IFNG in the Gut.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2009Article
- The production of interferon-gamma-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity.Journal of gastroenterology · 2007Article
- Critical comment: analyzing the effect of novel therapies on cytokine expression in inflammatory bowel disease: do cytokine levels reflect clinical response?International journal of colorectal disease · 2006Article
- Human intestinal epithelial and smooth muscle cells are potent producers of IL-6.Mediators of inflammation · 2003Article
- A polymorphism in the IL11 gene is associated with ulcerative colitis.Genes and immunity · 2002Article
- A coculture model mimicking the intestinal mucosa reveals a regulatory role for myofibroblasts in immune-mediated barrier disruption.Digestive diseases and sciences · 2002Article
- Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis.Clinical and experimental immunology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determination of plasma and tissue cytokine levels in inflammatory bowel disease have frequently resulted in conflicting data. In the present study we determined in patients with ulcerative colitis (UC), the levels of the proinflammatory cytokines interleukin (IL)-1beta, IL-6, interferon (IFN)-gamma, and tumor-necrosis factor (TNF)-alpha liberated by peripheral blood mononuclear cells (PBMC) and lamina propria mononuclear cells (LPMC) after 48-hr culture with pokeweed mitogen (PWM). IL-1beta, IL-6, IFN-gamma and TNF-alpha in the supernatant were detected by ELISA. Results show low basal levels of IL-1beta secretion by PBMC and LPMC, and a considerable increase after mitogen stimulation. Basal IL-6 production by PBMC was higher in UC patients than in controls [2029 pg/ml, CI95(-165 to 4223) vs 572 pg/ml (-383 to 1527) respectively, P = 0.05] and also after PWM activation [14,995 pg/ml (7759-22,230) vs 6598 pg/ml (3240-9956), respectively, P = 0.05]. In LPMC, no differences in IL-6 secretion were observed. TNF-alpha in activated PBMC of patients with UC was not significantly increased in relation to control (P = 0.09). No constitutive secretion of IFN-gamma was observed in mononuclear cells. IFN-gamma levels secreted by activated LPMC were lower in patients with UC than in controls [1571 pg/ml (-108 to 3251) vs 7953 pg/ml (3851-12,055), respectively, P = 0.03]. These results suggest that IL-6, IL-1beta, and TNF-alpha participate as mediators in the inflammatory phenomena observed in UC. Further studies are necessary to evaluate the role of IFN-gamma in this condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.