ReviewBrain pathology (Zurich, Switzerland)1999
The neurobiology of Schwann cells.
Review in Brain pathology (Zurich, Switzerland), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 242 citations in OpenAlex.
- Bridging the Gap: Contemporary Paradigms in Nerve Scaffolds and Regeneration.Advances in wound care · 2025Review
- The Role of Sensory Innervation in Homeostatic and Injury-Induced Corneal Epithelial Renewal.International journal of molecular sciences · 2023Review
- Preventive Effect of Local Lidocaine Administration on the Formation of Traumatic Neuroma.Journal of clinical medicine · 2023Article
- Far from home: the role of glial mRNA localization in synaptic plasticity.RNA (New York, N.Y.) · 2023Review
- Nerve Density and Neuronal Biomarkers in Cancer.Cancers · 2022Review
- The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1).PloS one · 2017Article
- Tissue-engineered rhesus monkey nerve grafts for the repair of long ulnar nerve defects: similar outcomes to autologous nerve grafts.Neural regeneration research · 2016Article
- Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling.Antioxidants & redox signaling · 2016Article
- Perineurial glia.Cold Spring Harbor perspectives in biology · 2015Review
- Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1(G93A) mouse model of Amyotrophic Lateral Sclerosis.Frontiers in cellular neuroscience · 2015Article
- Article
- Clinical translation of autologous Schwann cell transplantation for the treatment of spinal cord injury.Current opinion in organ transplantation · 2013Review
- Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death.Cell death & disease · 2013Article
- Characterization of schwann cells in self-assembled sheets from thermoresponsive substrates.Tissue engineering. Part A · 2013Article
- GABA-B receptors in the PNS have a role in Schwann cells differentiation?Frontiers in cellular neuroscience · 2012Article
- Transfer of vesicles from schwann cells to axons: a novel mechanism of communication in the peripheral nervous system.Frontiers in physiology · 2012Article
- Neural and molecular features on Charcot-Marie-Tooth disease plasticity and therapy.Neural plasticity · 2012Review
- Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial.BMC developmental biology · 2011Article
- Silk fibroin conduits: a cellular and functional assessment of peripheral nerve repair.Annals of plastic surgery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This selective review of Schwann cell biology focuses on questions relating to the origins, development and differentiation of Schwann cells and the signals that control these processes. The importance of neuregulins and their receptors in controlling Schwann cell precursor survival and generation of Schwann cells, and the role of these molecules in Schwann cell biology is addressed. The reciprocal signalling between peripheral glial cells and neurons in development and adult life revealed in recent years is highlighted, and the profound change in survival regulation from neuron-dependent Schwann cell precursors to adult Schwann cells that depend on autocrine survival signals is discussed. Besides providing neuronal and autocrine signals, Schwann cells signal to mesenchymal cells and influence the development of the connective tissue sheaths of peripheral nerves. The importance of Desert Hedgehog in this process is described. The control of gene expression during Schwann cell development and differentiation by transcription factors is reviewed. Knockout of Oct-6 and Krox-20 leads to delay or absence of myelination, and these results are related to morphological or physiological observations on knockout or mutation of myelin-related genes. Finally, the relationship between selected extracellular matrix components, integrins and the cytoskeleton is explored and related to disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.