ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1999
Extracellular glutamate diffusion determines the occupancy of glutamate receptors at CA1 synapses in the hippocampus.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- The impact of diffusion on receptor binding during synaptic transmission.Biophysical journal · 2024Article
- Estimation of cumulative amplitude distributions of miniature postsynaptic currents allows characterising their multimodality, quantal size and variability.Scientific reports · 2023Article
- Extending the minimal model of metabolic oscillations in Bacillus subtilis biofilms.Scientific reports · 2020Article
- δ subunit-containing GABAThe Journal of physiology · 2020Article
- Differential equation-based minimal model describing metabolic oscillations inRoyal Society open science · 2020Article
- The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Review
- Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.Frontiers in cellular neuroscience · 2018Article
- Article
- Calcium-Sensing Receptor: A Key Target for Extracellular Calcium Signaling in Neurons.Frontiers in physiology · 2016Review
- Brain extracellular matrix retains connectivity in neuronal networks.Scientific reports · 2015Article
- Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus.Journal of neurophysiology · 2015Article
- The perineuronal net component of the extracellular matrix in plasticity and epilepsy.Neurochemistry international · 2012Review
- Extrasynaptic glutamate receptor activation as cellular bases for dynamic range compression in pyramidal neurons.Frontiers in physiology · 2012Article
- From the stochasticity of molecular processes to the variability of synaptic transmission.Nature reviews. Neuroscience · 2011Review
- Simultaneous real-time measurement of EEG/EMG and L-glutamate in mice: A biosensor study of neuronal activity during sleep.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2011Article
- Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli.The Journal of physiology · 2011Article
- Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.Nature neuroscience · 2011Article
- Determining the neurotransmitter concentration profile at active synapses.Molecular neurobiology · 2009Review
- Calcium-sensing receptor activation depresses synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation.PLoS computational biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Following exocytosis at excitatory synapses in the brain, glutamate binds to several subtypes of postsynaptic receptors. The degree of occupancy of AMPA and NMDA receptors at hippocampal synapses is, however, not known. One approach to estimate receptor occupancy is to examine quantal amplitude fluctuations of postsynaptic signals in hippocampal neurons studied in vitro. The results of such experiments suggest that NMDA receptors at CA1 synapses are activated not only by glutamate released from the immediately apposed presynaptic terminals, but also by glutamate spillover from neighbouring terminals. Numerical simulations point to the extracellular diffusion coefficient as a critical parameter that determines the extent of activation of receptors positioned at different distances from the release site. We have shown that raising the viscosity of the extracellular medium can modulate the diffusion coefficient, providing an experimental tool to investigate the role of diffusion in activation of synaptic and extrasynaptic receptors. Whether intersynaptic cross-talk mediated by NMDA receptors occurs in vivo remains to be determined. The theoretical and experimental approaches described here also promise to shed light on the roles of metabotropic and kainate receptors, which often occur in an extrasynaptic distribution, and are therefore positioned to sense glutamate escaping from the synaptic cleft.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.