ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences1999
Properties of fast endocytosis at hippocampal synapses.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
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- Is replenishment of the readily releasable pool associated with vesicular movement?Cognitive neurodynamics · 2014Article
- Visualizing presynaptic function.Nature neuroscience · 2014Review
- Optical tracking of phenotypically diverse individual synapses on solitary tract nucleus neurons.Brain research · 2010Article
- Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Multiple vesicle recycling pathways in central synapses and their impact on neurotransmission.The Journal of physiology · 2007Review
- Deletion of CASK in mice is lethal and impairs synaptic function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Clathrin and synaptic vesicle endocytosis: studies at the squid giant synapse.Biochemical Society transactions · 2006Review
- Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Sustained stimulation shifts the mechanism of endocytosis from dynamin-1-dependent rapid endocytosis to clathrin- and dynamin-2-mediated slow endocytosis in chromaffin cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Development of vesicle pools during maturation of hippocampal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Synaptic vesicle endocytosis: the races, places, and molecular faces.Neuromolecular medicine · 2002Review
- ATP is required at an early step in compensatory endocytosis in synaptic terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Interaction of stoned and synaptotagmin in synaptic vesicle endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of synaptic transmission is a widespread means for dynamic alterations in nervous system function. In several cases, this regulation targets vesicular recycling in presynaptic terminals and may result in substantial changes in efficiency of synaptic transmission. Traditionally, experimental accessibility of the synaptic vesicle cycle in central neuronal synapses has been largely limited to the exocytotic side, which can be monitored with electrophysiological responses to neurotransmitter release. Recently, physiological measurements on the endocytotic portion of the cycle have been made possible by the introduction of styryl dyes such as FM1-43 as fluorescent markers for recycling synaptic vesicles. Here we demonstrate the existence of fast endocytosis in hippocampal nerve terminals and derive its kinetics from fluorescence measurements using dyes with varying rates of membrane departitioning. The rapid mode of vesicular retrieval was greatly speeded by exposure to staurosporine or elevated extracellular calcium. The effective time-constant for retrieval can be < 2 seconds under appropriate conditions. Thus, hippocampal synapses capitalize on efficient mechanisms for endocytosis and their vesicular retrieval is subject to modulatory control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.