ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 156 citations in OpenAlex.
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- GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.Cancer discovery · 2023Article
- Neuroregenerative and protective functions of Leukemia Inhibitory Factor in perinatal hypoxic-ischemic brain injury.Experimental neurology · 2020Article
- The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- LIF, a Novel Myokine, Protects Against Amyloid-Beta-Induced Neurotoxicity via Akt-Mediated Autophagy Signaling in Hippocampal Cells.The international journal of neuropsychopharmacology · 2019Article
- Determinants of Axon Growth, Plasticity, and Regeneration in the Context of Spinal Cord Injury.The American journal of pathology · 2018Review
- Article
- Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.Molecular & cellular proteomics : MCP · 2015Article
- Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.Experimental neurology · 2015Article
- Biomaterial Approaches to Enhancing Neurorestoration after Spinal Cord Injury: Strategies for Overcoming Inherent Biological Obstacles.BioMed research international · 2015Review
- Neuroprotective effect of leukemia inhibitory factor on antimycin A-induced oxidative injury in differentiated PC12 cells.Journal of molecular neuroscience : MN · 2013Article
- Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.PloS one · 2013Article
- Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Cytokines that promote nerve regeneration.Experimental neurology · 2012Article
- An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury.Stem cells and development · 2012Article
- Biodegradable biomatrices and bridging the injured spinal cord: the corticospinal tract as a proof of principle.Cell and tissue research · 2012Review
- Gene therapy approaches to enhancing plasticity and regeneration after spinal cord injury.Experimental neurology · 2012Review
- Peripheral nerve repair with cultured schwann cells: getting closer to the clinics.TheScientificWorldJournal · 2012Review
- Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury.BMC neuroscience · 2010Article
- Intrinsic response of thoracic propriospinal neurons to axotomy.BMC neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The cytokine leukemia inhibitory factor (LIF) modulates glial and neuronal function in development and after peripheral nerve injury, but little is known regarding its role in the injured adult CNS. To further understand the biological role of LIF and its potential mechanisms of action after CNS injury, effects of cellularly delivered LIF on axonal growth, glial activation, and expression of trophic factors were examined after adult mammalian spinal cord injury. Fibroblasts genetically modified to produce high amounts of LIF were grafted to the injured spinal cords of adult Fischer 344 rats. Two weeks after injury, animals with LIF-secreting cells showed a specific and significant increase in corticospinal axon growth compared with control animals. Furthermore, expression of neurotrophin-3, but not nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor, or ciliary neurotrophic factor, was increased at the lesion site in LIF-grafted but not in control subjects. No differences in astroglial and microglial/macrophage activation were observed. Thus, LIF can directly or indirectly modulate molecular and cellular responses of the adult CNS to injury. These findings also demonstrate that neurotrophic molecules can augment expression of other trophic factors in vivo after traumatic injury in the adult CNS.
Indexed as
Identifiers
10212315PMC6782234W2119409468What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.