ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Ca2+-permeable P2X receptor channels in cultured rat retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Pulmonary Vascular Signaling in Pulmonary Hypertension: Potential Role of Endothelial CaArteriosclerosis, thrombosis, and vascular biology · 2026Review
- Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma.PloS one · 2014Article
- Principles and properties of ion flow in P2X receptors.Frontiers in cellular neuroscience · 2014Review
- On the somatosensation of vision.Annals of neurosciences · 2012Review
- Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs.Pflugers Archiv : European journal of physiology · 2009Article
- The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance.Purinergic signalling · 2009Article
- P2X receptors in sensory neurons co-cultured with cancer cells exhibit a decrease in opioid sensitivity.The European journal of neuroscience · 2009Article
- The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance.Purinergic signalling · 2008Article
- Biophysics of P2X receptors.Pflugers Archiv : European journal of physiology · 2006Review
- ATP-induced non-neuronal cell permeabilization in the rat inner retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- A dialogue between glia and neurons in the retina: modulation of neuronal excitability.Neuron glia biology · 2004Article
- Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato-sensory cortex.The Journal of physiology · 2002Article
- Calcium and retinal function.Molecular neurobiology · 2002Review
- Developmental changes in P2X purinoceptors on glycinergic presynaptic nerve terminals projecting to rat substantia gelatinosa neurones.The Journal of physiology · 2001Article
- Open probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancy.The Journal of physiology · 2001Article
- Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia.The Journal of physiology · 2001Article
- Glia-derived signals induce synapse formation in neurones of the rat central nervous system.The Journal of physiology · 2001Article
- Propagation of intercellular calcium waves in retinal astrocytes and Müller cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- P2X7 receptors in Müller glial cells from the human retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Regulation of the on bipolar cell mGluR6 pathway by Ca2+.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP has been identified as an excitatory neurotransmitter in both the CNS and peripheral nervous system; however, little is known about the functional properties of ATP-gated channels in central neurons. Here we used a culture preparation of the postnatal rat retina to test the responsiveness of identified retinal ganglion cells (RGCs) and putative amacrines to exogenous ATP and other purinoceptor agonists. Rapidly activating ATP-induced currents (IATP) were exclusively generated in a subpopulation (approximately 65%) of RGCs. The latter were identified by Thy1.1 immunostaining, repetitive firing patterns, and activation of glutamatergic autaptic currents. None of the putative amacrine cells was ATP-sensitive. IATP could be induced with ATP, ADP, and alpha,beta-mATP but not with adenosine. It was antagonized by suramin. The current-voltage relationship of IATP showed marked inward rectification. Dose-response analysis yielded an EC50 of 14.5 microM, with a Hill coefficient of 0.9. Noise analysis of IATP suggested a mean single channel conductance of 2.3 pS. Retinal P2X purinoceptor channels exhibited a high permeability for Ca2+. PCa/PCs obtained from reversal potentials of IATP under bi-ionic conditions amounted to 2. 2 +/- 0.7. In the majority of cells, the decay of IATP was biphasic. The degree of current inactivation during the first 2 sec of agonist application was highly variable. Heterogeneity was also found with respect to the sensitivity to ADP and alpha,beta-mATP and the blocking action of suramin, suggesting expression of multiple P2X receptor subtypes. Our results indicate that activation of P2X receptor channels represents an important pathway for Ca2+ influx in postnatal RGCs.
Indexed as
Identifiers
10212295PMC6782237W2103533677What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.