ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Genetic dissection of behavior: modulation of locomotion by light in the Drosophila melanogaster larva requires genetically distinct visual system functions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 81 citations in OpenAlex.
- Assessing phototaxis behavior in non-resistant and insecticide-resistant populations of Hyalella azteca.Ecotoxicology (London, England) · 2026Article
- Multi-neuronal recording in unrestrained animals with all acousto-optic random-access line-scanning two-photon microscopy.Frontiers in neuroscience · 2023Article
- A simple high-throughput method for automated detection of Drosophila melanogaster light-dependent behaviours.BMC biology · 2022Article
- Light exposure during development affects physiology of adults inFrontiers in physiology · 2022Article
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- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
- Modelling the mechanics of exploration in larval Drosophila.PLoS computational biology · 2019Article
- Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.Scientific reports · 2017Article
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- Age- and Wavelength-Dependency ofFrontiers in behavioral neuroscience · 2017Article
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- Computations underlying Drosophila photo-taxis, odor-taxis, and multi-sensory integration.eLife · 2015Article
- Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans.PLoS genetics · 2015Article
- Sensorimotor structure of Drosophila larva phototaxis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- High-throughput analysis of stimulus-evoked behaviors in Drosophila larva reveals multiple modality-specific escape strategies.PloS one · 2013Article
- Automated tracking of animal posture and movement during exploration and sensory orientation behaviors.PloS one · 2012Article
- Growing pains: development of the larval nocifensive response in Drosophila.The Biological bulletin · 2011Article
- XPORT-dependent transport of TRP and rhodopsin.Neuron · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila larva modulates its pattern of locomotion when exposed to light. Modulation of locomotion can be measured as a reduction in the distance traveled and by a sharp change of direction when the light is turned on. When the light is turned off this change of direction, albeit significantly smaller than when the light is turned on, is still significantly larger than in the absence of light transition. Mutations that disrupt adult phototransduction disrupt a subset of these responses. In larvae carrying these mutations the magnitude of change of direction when the light is turned on is reduced to levels indistinguishable from that recorded when the light is turned off, but it is still significantly higher than in the absence of any light transition. Similar results were obtained when these responses were measured in strains where the larval photoreceptor neurons were ablated by mutations in the glass (gl) gene or by the targeted expression of the cell death gene head involution defective (hid). A mutation in the homeobox gene sine oculis (so) that ablates the larval visual system, or the targeted expression of the reaper (rpr) cell death gene, abolishes all responses to light detected as a change of direction. We propose the existence of an extraocular light perception that does not use the same phototransduction cascade as the adult photoreceptors. Our results indicate that this novel visual function depends on the blue-absorbing rhodopsin Rh1 and is specified by the so gene.
Indexed as
Identifiers
10212293PMC6782248W2144199652What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.