ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 128 citations in OpenAlex.
- Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets.Food & function · 2017Trial
- Rhythmic patterns in microglial cells within the circadian pineal gland from male rats.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Exploring the Effects of Blue Light on Circadian Rhythm in SD Rat.Nature and science of sleep · 2026Article
- Regulation of CRE-Dependent Transcriptional Activity in a Mouse Suprachiasmatic Nucleus Cell Line.International journal of molecular sciences · 2022Article
- The Role of the Melatoninergic System in Circadian and Seasonal Rhythms-Insights From Different Mouse Strains.Frontiers in physiology · 2022Review
- The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation.Life (Basel, Switzerland) · 2021Article
- Identifying daily changes in circRNAs and circRNA-associated-ceRNA networks in the rat pineal gland.International journal of medical sciences · 2021Article
- Article
- Pineal gland dysfunction in Alzheimer's disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis.Molecular neurodegeneration · 2019Review
- Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency.Journal of pineal research · 2019Article
- Adrenergic activation of melatonin secretion in ovine pineal explants in short-term superfusion culture occurs via protein synthesis independent and dependent phenomena.BioMed research international · 2014Article
- Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.The Journal of biological chemistry · 2013Article
- Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation.BioMed research international · 2013Article
- Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription.PloS one · 2012Article
- Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism.The Journal of biological chemistry · 2011Article
- Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors.Molecular and cellular biology · 2010Article
- Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
- Inducible cAMP early repressor (ICER) and brain functions.Molecular neurobiology · 2009Review
- The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis.Neuroscience · 2008Article
- ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Neurotransmitter-driven activation of transcription factors is important for control of neuronal and neuroendocrine functions. We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). pCREB accumulates endogenously at the beginning of the dark period and declines during the second half of the night. Concomitant with this decline, the amount of ICER rises. The changing ratio between pCREB and ICER shapes the in vivo dynamics in mRNA and, thus, protein levels of arylalkylamine-N-acetyltransferase, the rate-limiting enzyme of melatonin synthesis. Consequently, a silenced ICER expression in pinealocytes leads to a disinhibited arylalkylamine-N-acetyltransferase transcription and a primarily enhanced melatonin synthesis.
Indexed as
Identifiers
10212292PMC6782257W1961435330What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.