ArticleThorax1999
Use of the General Practice Research Database (GPRD) for respiratory epidemiology: a comparison with the 4th Morbidity Survey in General Practice (MSGP4).
Article in Thorax, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01729351 (Comparative Effectiveness of Extrafine Hydrofluoroalkane Beclometasone Versus Fluticasone and Chlorofluorocarbon Beclometasone in Smoking Asthma - a Retrospective, Real-life Observational Study in a UK Primary Care Asthma Population), which is not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effectiveness of Extrafine Hydrofluoroalkane Beclometasone Versus Fluticasone and Chlorofluorocarbon Beclometasone in Smoking Asthma - a Retrospective, Real-life Observational Study in a UK Primary Care Asthma Population
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Combining Geospatial Analysis with Dementia Risk Utilising General Practice Data: A Systematic Review.The journal of prevention of Alzheimer's disease · 2018Pooled it
- Validity of diagnostic coding within the General Practice Research Database: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010Pooled it
- Systematic review of scope and quality of electronic patient record data in primary care.BMJ (Clinical research ed.) · 2003Pooled it
- Trial
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- Program for data extraction in primary health records: a valid tool for knowledge production in general practice?BMC research notes · 2020Article
- Incidence, Prevalence, and Survival of Patients with Idiopathic Pulmonary Fibrosis in the UK.Advances in therapy · 2018Article
- Cardiovascular Outcomes after a Respiratory Tract Infection among Adults with Non-Cystic Fibrosis Bronchiectasis: A General Population-based Study.Annals of the American Thoracic Society · 2018Article
- A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink.Clinical epidemiology · 2018Article
- Childhood asthma prevalence: cross-sectional record linkage study comparing parent-reported wheeze with general practitioner-recorded asthma diagnoses from primary care electronic health records in Wales.BMJ open respiratory research · 2018Article
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- Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study.The European respiratory journal · 2016Article
- Risk of community-acquired pneumonia in patients with a diagnosis of pernicious anemia: a population-based retrospective cohort study.European journal of gastroenterology & hepatology · 2015Article
- Can different primary care databases produce comparable estimates of burden of disease: results of a study exploring venous leg ulceration.Family practice · 2015Article
- Using an electronic medical record (EMR) to conduct clinical trials: Salford Lung Study feasibility.BMC medical informatics and decision making · 2015Article
- Reuse of clinical data.Yearbook of medical informatics · 2014Review
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- Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research.Journal of the American Medical Informatics Association : JAMIA · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe General Practice Research Database (GPRD) covers over 6% of the population of England and Wales and holds data on diagnoses and prescribing from 1987 onwards. Most previous studies using the GPRD have concentrated on drug use and safety. A study was undertaken to assess the validity of using the GPRD for epidemiological research into respiratory diseases.
methodsAge-specific and sex-specific rates derived from the GPRD for 11 respiratory conditions were compared with patient consultation rates from the 4th Morbidity Survey in General Practice (MSGP4). Within the GPRD comparisons were made between patient diagnosis rates, patient prescription rates, and patient "prescription plus relevant diagnosis" rates for selected treatments.
resultsThere was good agreement between consultation rates in the MSGP4 and diagnosis or "prescription plus diagnosis" from the GPRD in terms of pattern and magnitude, except for "acute bronchitis or bronchiolitis" where the best comparison was the combination category of "chest infection" and/or "acute bronchitis or bronchiolitis". Within the GPRD, patient prescription rates for inhalers, tuberculosis or hayfever therapy showed little similarity with diagnosis only rates but a similarity was seen with the combination of "prescription plus diagnosis" which may be a better reflection of morbidity than diagnosis alone.
conclusionsThe GPRD appears to be valid for primary care epidemiological studies by comparison with MSGP4 and offers advantages in terms of large size, a longer time period covered, and ability to link prescriptions with diagnoses. However, careful interpretation is needed because not all consultations are recorded and the coding system used contains terms which do not directly map to ICD codes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.