ArticleClinical and experimental immunology1999
Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Cell death pathways in response toInfection and immunity · 2025Review
- TNFR1 Mediated Apoptosis Is Protective againstMicroorganisms · 2023Article
- Review
- Genetic Involvement ofInternational journal of molecular sciences · 2021Review
- Nontuberculous Mycobacteria Persistence in a Cell Model Mimicking Alveolar Macrophages.Microorganisms · 2019Article
- TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages.Frontiers in cell and developmental biology · 2019Review
- TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling.Cell death & disease · 2018Article
- The Voltage-Dependent Anion Channels (VDAC) of Mycobacterium avium phagosome are associated with bacterial survival and lipid export in macrophages.Scientific reports · 2017Article
- Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth.Scientific reports · 2016Article
- Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis.Cell death & disease · 2016Article
- Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models.Antimicrobial agents and chemotherapy · 2015Article
- Infection of Primary Bovine Macrophages with Mycobacterium avium Subspecies paratuberculosis Suppresses Host Cell Apoptosis.Frontiers in microbiology · 2012Article
- Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection.PloS one · 2011Article
- Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages.PloS one · 2010Article
- Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response.Clinical and experimental immunology · 2007Article
- Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infection.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Whipple's disease: a macrophage disease.Clinical and vaccine immunology : CVI · 2006Review
- Differential gene expression in mononuclear phagocytes infected with pathogenic and non-pathogenic mycobacteria.Clinical and experimental immunology · 2004Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mycobacterium avium causes disseminated infection in AIDS patients and several forms of infection in immunocompetent hosts. Recent studies have shown that M. avium infection of macrophages in vitro leads to apoptosis of significant numbers of infected cells. Several strains of M. avium used to infect human macrophages for 5 days (multiplicity of infection of 10) triggered 28-46% higher levels of apoptosis than observed with uninfected macrophages at the same time points. Mycobacterium avium strains unable to replicate intracellularly (rep-) resulted in a 15% rate of apoptosis, while M. smegmatis-infected monolayers showed the same percentage of apoptotic cells as the uninfected macrophage control. The presence of anti-TNF-alpha antibody reduced apoptosis to 17% and the presence of anti-Fas antibody reduced apoptosis to 10%. When both antibodies were used together, the apoptosis level was 5% above the control. Treatment with TGF-beta also reduced the number of apoptotic cells in infected monolayers. If intracellular growth was inhibited, apoptosis of macrophages decreased significantly. It was also shown that apoptosis was associated with IL-1 beta-converting enzyme (ICE) activation and was significantly reduced by a caspase inhibitor. Gaining understanding of the mechanisms of M. avium-associated apoptosis of macrophages will provide important insight into M. avium pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.