ArticleThe Journal of experimental medicine1999
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology--a systematic review.BMC veterinary research · 2013Pooled it
- Mucosal Responses to Type II Interferon in IBD.Inflammatory bowel diseases · 2025Article
- Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification.Inflammopharmacology · 2024Article
- Human intestinal B cells in inflammatory diseases.Nature reviews. Gastroenterology & hepatology · 2023Review
- Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation.Chembiochem : a European journal of chemical biology · 2023Article
- Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease.International journal of molecular sciences · 2022Review
- Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
- Preclinical Study in Vivo for New Pharmacological Approaches in Inflammatory Bowel Disease: A Systematic Review of Chronic Model of TNBS-Induced Colitis.Journal of clinical medicine · 2019Review
- A Versatile New Model of Chemically Induced Chronic Colitis Using an Outbred Murine Strain.Frontiers in microbiology · 2018Article
- The regulation of gut mucosal IgA B-cell responses: recent developments.Mucosal immunology · 2017Review
- Chemically induced mouse models of acute and chronic intestinal inflammation.Nature protocols · 2017Article
- A lactic acid bacterium isolated from kimchi ameliorates intestinal inflammation in DSS-induced colitis.Journal of microbiology (Seoul, Korea) · 2017Article
- Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Experimental Models of Inflammatory Bowel Diseases.Cellular and molecular gastroenterology and hepatology · 2015Article
- LPS-induced systemic inflammation is more severe in P2Y12 null mice.Journal of leukocyte biology · 2014Article
- The Mechanisms of M-cell Differentiation.Bioscience of microbiota, food and health · 2014Review
- Review
- The role of Peyer's patches in synchronizing gut IgA responses.Frontiers in immunology · 2012Article
- Perinodal adipose tissue and mesenteric lymph node activation during reactivated TNBS-colitis in rats.Digestive diseases and sciences · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
To investigate the potential involvement of T helper (Th)2-type responses in murine models of intestinal inflammation, we used trinitrobenzene sulfonic acid (TNBS)-hapten to induce inflammatory bowel disease in situations where Th1-type responses with interferon (IFN)-gamma synthesis are either diminished or do not occur. Intracolonic administration of TNBS to either normal (IFN-gamma+/+) or Th1-deficient IFN-gamma knockout (IFN-gamma-/-) BALB/c mice resulted in significant colitis. In IFN-gamma-/- mice, crypt inflammation was more severe than in IFN-gamma+/+ mice and was accompanied by hypertrophy of colonic patches with a lymphoepithelium containing M cells and distinct B and T cell zones resembling Peyer's patches. Hapten-specific, colonic patch T cells from both mouse groups exhibited a Th2 phenotype with interleukin (IL)-4 and IL-5 production. TNBS colitis in normal mice treated with anti-IL-4 antibodies or in IL-4(-/-) mice was less severe than in either IFN-gamma+/+ or IFN-gamma-/- mice. Our findings now show that the Th2-type responses in TNBS colitis are associated with colonic patch enlargement and inflammation of the mucosal layer and may represent a model for ulcerative colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.