ArticleOncogene1999
Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
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- Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes.Oncology letters · 2015Article
- Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.PloS one · 2015Article
- Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma.World journal of gastroenterology · 2014Article
- Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms.Yonago acta medica · 2014Review
- Overexpression of ETV4 protein in triple-negative breast cancer is associated with a higher risk of distant metastasis.OncoTargets and therapy · 2014Article
- Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition.Oncogenesis · 2012Article
- PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma.British journal of cancer · 2011Article
- EGF-receptor regulation of matrix metalloproteinases in epithelial ovarian carcinoma.Future oncology (London, England) · 2009Review
- PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells.Molecular cancer research : MCR · 2007Article
- Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase.Clinical & experimental metastasis · 2006Article
- Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.Oncogene · 2005Article
- Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo.Journal of cancer research and clinical oncology · 2005Article
- Expression and localization of membrane-type-1 matrix metalloproteinase, CD 44, and laminin-5gamma2 chain during colorectal carcinoma tumor progression.Virchows Archiv : an international journal of pathology · 2004Article
- Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition.The American journal of pathology · 2002Article
- Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells.The American journal of pathology · 2002Article
- The Ets-transcription factor family in embryonic development: lessons from the amphibian and bird.Oncogene · 2000Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the role of E1AF, a member of ets family transcription factor, in the acquisition of metastatic capacity by non-metastatic mouse fibrosarcoma cell clone, QR-32. The QR-32 cell clone grows progressively after co-implantation with gelatin sponge in syngeneic C57BL/6 mice. The cell lines (QRsP) established from arising tumors after the co-implantation exhibited enhanced tumorigenicity and pulmonary metastasis in vivo as compared with parent QR-32 cells. The enhanced pulmonary metastasis of QRsP cells was correlated well with augmented production of matrix metalloproteinase-2 (MMP-2) and increased expression of membrane-type 1-MMP (MT1-MMP). The QRsP cells also acquired higher chemokinetic activities to fibronectin and higher invasive activities through a reconstituted basement membrane. Furthermore we observed the elevated mRNA expression of E1AF in QRsP cells compared to parent QR-32 cells. Therefore, we transfected QR-32 cells with E1AF cDNA. Overexpression of E1AF in the QR-32 cells resulted in the induction of MT1-MMP expression and converting an exogenously added precursor MMP-2 into active form. E1AF transfectants exhibited more motile and invasive activities, and moderately increased pulmonary metastatic activities than parental QR-32 cells in vivo, although their metastatic activities were lower than those of QRsP cells. These findings suggest that the increased expression of E1AF in fibrosarcoma contributes to invasive phenotypes including MT1-MMP expression and enhanced cell migration, but not sufficient for exhibiting highly metastatic activity in vivo.
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