ArticleOncogene1999
Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Increased expression of HPV-E7 oncoprotein correlates with a reduced level of pRb proteins via high viral load in cervical cancer.Scientific reports · 2023Article
- IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands.Molecular and cellular biology · 2013Article
- E2F4 plays a key role in Burkitt lymphoma tumorigenesis.Leukemia · 2012Article
- Review
- Cardiac myocyte cell cycle control in development, disease, and regeneration.Physiological reviews · 2007Review
- Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb.Molecular and cellular biology · 2005Article
- Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.Journal of virology · 2004Article
- Article
- The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).Genes & development · 2002Article
- An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase.The Biochemical journal · 2002Article
- Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.Molecular and cellular biology · 2002Article
- Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.The EMBO journal · 2001Article
- Apoptosis and cell growth inhibition as antitumor effector functions of interferons.Medical oncology (Northwood, London, England) · 2001Review
- Article
- Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation.Molecular and cellular biology · 2000Article
- Deregulated E2F transcriptional activity in autonomously growing melanoma cells.The Journal of experimental medicine · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E2F is a heterodimeric transcription factor composed of one of five E2F subunits (E2F-1 to E2F-5) and a DP subunit. E2F regulates the expression of several growth-promoting genes, and thus, can be a target of antiproliferative action of interferons (IFNs). In this study, we investigated the mechanisms whereby IFN-alpha suppresses transcription of the E2F-1 gene. Transfection studies revealed that E2F-1 promoter was functionally divided into two parts: upstream activation sequences (UAS) and a downstream negative-regulatory element (E2F-binding sites). When cells were proliferating, transcription of the E2F-1 gene was primarily driven by the UAS, while E2F sites were not involved in activation. IFN-alpha markedly reduced E2F-1 promoter activity, but introduction of non-binding mutation at the E2F sites completely abrogated the inhibition. Free E2F4 was found to be the predominant species bound to the E2F sites in proliferating cells. IFN-alpha induced upregulation of E2F-4 along with dephosphorylation of pRB and p130, which resulted in the formation of E2F-4/pRB and E2F-4/p130 complexes on the E2F-1 promoter. These complexes function as transcriptional repressors to inhibit E2F-1 mRNA expression. Our findings indicate that E2F-4 is a critical regulator of E2F-1, which offer an excellent paradigm for understanding functional diversity within the E2F family.
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.