ArticleThe Journal of clinical investigation1999
Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 106 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- PlasmaMetabolomics : Official journal of the Metabolomic Society · 2026Article
- Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.Nature structural & molecular biology · 2025Article
- Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.Nature genetics · 2023Article
- Citric Acid: A Multifunctional Pharmaceutical Excipient.Pharmaceutics · 2022Review
- Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis.Aging cell · 2021Article
- Compartmentalised acyl-CoA metabolism and roles in chromatin regulation.Molecular metabolism · 2020Review
- Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy.Oxidative medicine and cellular longevity · 2019Review
- Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells.International journal of molecular sciences · 2018Article
- Localization of the calcium-regulated citrate transport process in proximal tubule cells.Urolithiasis · 2014Article
- Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice.The Journal of biological chemistry · 2014Article
- Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family.Pflugers Archiv : European journal of physiology · 2014Review
- The Role of INDY in Metabolic Regulation.Computational and structural biotechnology journal · 2013Review
- PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.Investigative ophthalmology & visual science · 2011Article
- High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1.Mechanisms of ageing and development · 2010Article
- Hypocitraturia: pathophysiology and medical management.Reviews in urology · 2009Article
- Use of genetic immunization to generate a high-level antibody against rat dicarboxylate transporter.International urology and nephrology · 2009Article
- The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros.PLoS genetics · 2007Article
- Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus.Journal of bacteriology · 2007Article
- Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter.Biochimica et biophysica acta · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Kidney proximal tubule cells take up Krebs cycle intermediates for metabolic purposes and for secretion of organic anions through dicarboxylate/organic anion exchange. Alteration in reabsorption of citrate is closely related to renal stone formation. The presence of distinct types of sodium-coupled dicarboxylate transporters has been postulated on either side of the polarized epithelial membrane in the kidney proximal tubule. Using a PCR-based approach, we isolated a novel member of the sodium-dependent dicarboxylate/sulfate transporter called SDCT2. SDCT2 is a 600-amino acid residue protein that has 47-48% amino acid identity to SDCT1 and NaDC-1, previously identified in kidney and intestine. Northern analysis gave a single band of 3.3 kb for SDCT2 in kidney, liver, and brain. In situ hybridization revealed that SDCT2 is prominently expressed in kidney proximal tubule S3 segments and in perivenous hepatocytes, consistent with the sites of high-affinity dicarboxylate transport identified based on vesicle studies. A signal was also detected in the meningeal layers of the brain. SDCT2 expressed in Xenopus oocytes mediated sodium-dependent transport of di- and tricarboxylates with substrate preference for succinate rather than citrate, but excluding monocarboxylates. SDCT2, unlike SDCT1, displayed a unique pH dependence for succinate transport (optimal pH 7.5-8.5) and showed a high affinity for dimethylsuccinate, two features characteristic of basolateral transport. These data help to interpret the mechanisms of renal citrate transport, their alteration in pathophysiological conditions, and their role in the elimination of organic anions and therapeutic drugs.
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