ArticleMolecular and cellular biology1999
Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Efficient GFP-labeling and analysis of spermatogenic cells using the IRG transgene and flow cytometry.Genesis (New York, N.Y. : 2000) · 2019Article
- Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.Molecular & cellular proteomics : MCP · 2013Article
- Quantitative analysis of mRNA translation in mammalian spermatogenic cells with sucrose and Nycodenz gradients.Reproductive biology and endocrinology : RB&E · 2010Article
- Article
- Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.Free radical biology & medicine · 2007Article
- Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse.Advances in experimental medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
During mammalian spermatogenesis, meiosis is followed by a brief period of high transcriptional activity. At this time a large amount of mRNA is stored as messenger ribonucleoprotein (mRNP) particles. All subsequent processes of sperm maturation occur in the complete absence of transcription, primarily using proteins which are newly synthesized from these stored mRNAs. By expressing transgene mRNAs in the early haploid spermatids of mice, we have investigated the sequence requirements for determining whether specific mRNAs in these cells will be stored as mRNP particles or be assembled into polysomes. The results suggest that mRNAs which are transcribed in spermatids are assembled into mRNP particles by a mechanism that acts independently of mRNA sequence. Our findings reveal a fundamental similarity between the mechanisms of translational control used in spermatogenesis and oogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.