ArticleMolecular and cellular biology1999
Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1-5 and Therapeutic Implications in Neuroendocrine and Non-Neuroendocrine Malignancies.International journal of cancer · 2026Review
- Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.The international journal of neuropsychopharmacology · 2025Article
- Expanding the Phenotypic Spectrum ofMolecular syndromology · 2022Article
- Neurodevelopmental profile of HIVEP2-related disorder.Developmental medicine and child neurology · 2022Article
- Transcription factor 4 and its association with psychiatric disorders.Translational psychiatry · 2021Review
- NovelMolecular syndromology · 2019Article
- International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature.Pharmacological reviews · 2018Review
- Mutations in HIVEP2 are associated with developmental delay, intellectual disability, and dysmorphic features.Neurogenetics · 2016Article
- Loss-of-function variants in HIVEP2 are a cause of intellectual disability.European journal of human genetics : EJHG · 2016Article
- Genome-wide repression of NF-κB target genes by transcription factor MIBP1 and its modulation by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase.The Journal of biological chemistry · 2012Article
- Article
- Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.Gene expression · 2007Article
- Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.BMC neuroscience · 2006Article
- The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study.BMC immunology · 2002Article
- ZAS: C2H2 zinc finger proteins involved in growth and development.Gene expression · 2002Review
- FHL2, a novel tissue-specific coactivator of the androgen receptor.The EMBO journal · 2000Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatostatin receptor type II expression in the mammalian brain displays a spatially and temporally very restricted pattern. In an investigation of the molecular mechanisms controlling these patterns, we have recently shown that binding of the transcription factor SEF-2 to a novel initiator element in the SSTR-2 promoter is essential for SSTR-2 gene expression. Further characterization of the promoter identified a species-conserved TC-rich enhancer element. By screening a mouse brain cDNA expression library, we cloned a cDNA encoding the transcription factor MIBP1. MIBP1 interacts specifically with both the TC box in the SSTR-2 promoter and with the SEF-2 initiator-binding protein to enhance transcription from the basal SSTR-2 promoter. We then investigated SSTR-2, SEF-2, and MIBP1 mRNA expression patterns in the developing and adult murine brain by Northern blotting and in situ hybridization. While SEF-2 is widely expressed in many neuronal and nonneuronal tissues, MIBP1 expression overlapped precisely with expression of SSTR-2 in the frontal cortex and hippocampus. In summary, our data for the first time define a regulatory role for the transcription factor MIBP1 in mediating spatially and temporally regulated SSTR-2 expression in the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.