ArticleMolecular and cellular biology1999
Identification of the novel player deltaEF1 in estrogen transcriptional cascades.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration.Cytokine & growth factor reviews · 2025Review
- EMT Features in Claudin-Low versus Claudin-Non-Suppressed Breast Cancers and the Role of Epigenetic Modifications.Current issues in molecular biology · 2023Article
- Epithelial-mesenchymal transition and its transcription factors.Bioscience reports · 2022Review
- Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation.Journal of clinical medicine · 2016Review
- Epstein-Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Identification of novel regulatory genes in development of the avian reproductive tracts.PloS one · 2014Article
- EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.Cellular and molecular life sciences : CMLS · 2012Review
- A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice.PLoS genetics · 2011Article
- ZEB1 is estrogen responsive in vitro in human foreskin cells and is over expressed in penile skin in patients with severe hypospadias.The Journal of urology · 2011Article
- Replication of the TCF4 intronic variant in late-onset Fuchs corneal dystrophy and evidence of independence from the FCD2 locus.Investigative ophthalmology & visual science · 2011Article
- Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor.International journal of endocrinology · 2011Article
- Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells.Breast cancer research and treatment · 2010Article
- Article
- Interferon regulatory factors (IRFs) repress transcription of the chicken ovalbumin gene.Gene · 2009Article
- Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights.Molecular and cellular biochemistry · 2008Article
- Zeb1 links epithelial-mesenchymal transition and cellular senescence.Development (Cambridge, England) · 2008Article
- The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1.The Biochemical journal · 2007Article
- BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells.BMC cancer · 2007Article
- YY1 binds to regulatory element of chicken lysozyme and ovalbumin promoters.Cytotechnology · 2006Article
- Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.The EMBO journal · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although many genes are regulated by estrogen, very few have been shown to directly bind the estrogen receptor complex. Therefore, transcriptional cascades probably occur in which the estrogen receptor directly binds to a target gene that encodes another transcription factor that subsequently regulates additional genes. Through the use of a differential display assay, a transcription factor has been identified that may be involved in estrogen transcriptional cascades. This report demonstrates that transcription factor deltaEF1 is induced eightfold by estrogen in the chick oviduct. Furthermore, the regulation by estrogen occurs at the transcriptional level and is likely to be a direct effect of the estrogen receptor complex, as it does not require concomitant protein synthesis. A putative binding site was identified in the 5'-flanking region of the chick ovalbumin gene identifying it as a possible target gene for regulation by deltaEF1. Characterization of this binding site revealed that deltaEF1 binds to and regulates the chick ovalbumin gene. Thus, a novel regulatory cascade that is triggered by estrogen has been defined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.