ArticleAmerican journal of human genetics1999
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 161 citations in OpenAlex.
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- Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.Human genomics · 2021Article
- A Compound Heterozygous Mutation of Lipase Maturation Factor 1 is Responsible for Hypertriglyceridemia of a Patient.Journal of atherosclerosis and thrombosis · 2019Article
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- Next-generation gene discovery for variants of large impact on lipid traits.Current opinion in lipidology · 2015Review
- PSEUDOMARKER 2.0: efficient computation of likelihoods using NOMAD.BMC bioinformatics · 2014Article
- Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats.Lipids in health and disease · 2014Article
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- Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease.European journal of human genetics : EJHG · 2010Article
- Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia.Human genetics · 2010Article
- Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Genome-wide linkage scan for plasma high density lipoprotein cholesterol, apolipoprotein A-1 and triglyceride variation among American Indian populations: the Strong Heart Family Study.Journal of medical genetics · 2009Article
- Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships.Archives of neurology · 2009Article
- Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study.Diabetes · 2009Article
- Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate.Human heredity · 2009Article
- TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.Diabetologia · 2008Article
- A male-specific quantitative trait locus on 1p21 controlling human stature.Journal of medical genetics · 2005Article
- A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region.Human genetics · 2005Article
- Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study.Human genetics · 2004Article
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial combined hyperlipidemia (FCHL) is a common dyslipidemia predisposing to premature coronary heart disease (CHD). The disease is characterized by increased levels of serum total cholesterol (TC), triglycerides (TGs), or both. We recently localized the first locus for FCHL, on chromosome 1q21-q23. In the present study, a genomewide screen for additional FCHL loci was performed. In stage 1, we genotyped 368 polymorphic markers in 35 carefully characterized Finnish FCHL families. We identified six chromosomal regions with markers showing LOD score (Z) values >1.0, by using a dominant mode of inheritance for the FCHL trait. In addition, two more regions emerged showing Z>2.0 with a TG trait. In stage 2, we genotyped 26 more markers and seven additional FCHL families for these interesting regions. Two chromosomal regions revealed Z>2.0 in the linkage analysis: 10p11.2, Z=3.20 (theta=.00), with the TG trait; and 21q21, Z=2.24 (theta=.10), with the apoB trait. Furthermore, two more chromosomal regions produced Z>2.0 in the affected-sib-pair analysis: 10q11.2-10qter produced Z=2.59 with the TC trait and Z=2.29 with FCHL, and 2q31 produced Z=2.25 with the TG trait. Our results suggest additional putative loci influencing FCHL in Finnish families, some potentially affecting TG levels and some potentially affecting TC or apoB levels.
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